糖尿病患者股神经的刺激阈值和对罗哌卡因敏感性分析  

Analysis of stimulation threshold and sensitivity to ropivacaine of femoral nerve in diabetic patients

作　　者：赵聪聪 周海滨[1] 阿依夏·那万 郗扬 彭云[1] 王佳[1] ZHAO Cong-cong;ZHOU Hai-bin;AYIXIA Na-wan;XI Yang;PENG Yun;WANG Jia(Department of Anesthesia,Beijing Jishuitan Hospital,Beijing 100035,China)

机构地区：[1]北京积水潭医院麻醉科,北京100035

出　　处：《临床药物治疗杂志》2022年第12期67-70,共4页Clinical Medication Journal

摘　　要：目的研究糖尿病患者股神经的刺激阈值和对罗哌卡因的敏感性。方法纳入北京积水潭医院2021年1—3月在椎管内麻醉下行全膝关节置换手术的患者,将非糖尿病患者作为对照组、糖尿病患者作为观察组。首先用超声联合神经刺激仪分别检测观察组和对照组患者股神经的刺激阈值;股神经阻滞后分别于1、5、15、30 min对两组患者股神经进行感觉功能和运动功能评分。结果阻滞前,对照组和观察组股神经的刺激阈值分别是(0.29±0.09)mA和(0.27±0.21)mA,差异无统计学意义(P>0.05)。感觉功能方面,阻滞后1、15和30 min两组患者各分级得分情况差异无统计学意义(均P>0.05);而阻滞后5 min,观察组功能得分低于对照组,差异有统计学意义(P<0.05)。运动功能方面,阻滞后1和30 min两组患者运动功能得分差异无统计学意义(均P>0.05);阻滞后5和15 min,观察组患者得分高于对照组,差异均有统计学意义(均P<0.05)。结论与非糖尿病患者相比,糖尿病患者股神经对罗哌卡因的敏感性增加,但刺激阈值无明显改变。Objective To investigate the stimulation threshold of femoral nerve and the sensitivity to ropivacaine in diabetic patients.Methods Patients who underwent total knee arthroplasty under spinal anesthesia in Beijing Jishuitan Hospital from January to March 2021 were included.Non-diabetic patients were selected as control group and diabetic patients were as observation group.The stimulation threshold of femoral nerve was measured by ultrasound combined with nerve stimulator.The sensory and motor function of the femoral nerve was evaluated at 1、5、15 and 30min after femoral never block.Results Before the block,the stimulation thresholds of the femoral nerve in the control group and the observation group were(0.29±0.09)mA and(0.27±0.21)mA respectively,and there was no significant difference(P>0.05).In terms of sensory function,there was no significant difference in the scores between the two group at 1,15 and 30 min after block(all P>0.05);at 5 min after block,the scores of the observation group were lower than those of the control group,the difference was significant(P<0.05).There was no significant difference in motor function between the two groups at 1 and 30 min after block(all P>0.05);at 5 min and 15 min after block,the score of Observation Group was higher than that of control group,the difference was significant(P<0.05).Conclusion Compared with non-diabetic patients,the femoral nerve stimulation threshold of diabetic patients did not change significantly,but the sensitivity to ropivacaine is increased.

关 键 词：糖尿病 股神经阻滞 罗哌卡因 阈值 

分 类 号：R971.2[医药卫生—药品] R587.1[医药卫生—药学]