猫血液生理生化指标正常范围探索与影响因素分析  

Exploration of Normal Range of Blood Physiological and Biochemical Indexes in Cats and Analysis of Influencing Factors

作　　者：王周祥 胡曼丽 陈芸 丁一[3] 赵德明[4] 贺争鸣[5] 张鑫 万娟 WANG Zhouxiang;HU Manli;CHEN Yun;DING Yi;ZHAO Deming;HE Zhengming;ZHANG Xin;WAN Juan(Gannan Innovation and Translational Medicine Research Institue,Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases,Ministry of Education,First Affiliated Hospital of Gannan Medical University,Gannan Medical University,Ganzhou 341000,China;Shanghai Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Shanghai 200241,China;Veterinary Medicine College,Huazhong Agricultural University,Wuhan 430070,China;College of Veterinary Medicine,China Agricultural University,Beijing 100193,China;National Institutes of Food And Drug Control,Beijing 100050,China)

机构地区：[1]赣南创新与转化医学研究院心脑血管疾病防治教育部重点实验室赣南医学院附属第一医院赣南医学院,赣州341000 [2]中国农业科学院上海兽医研究所,上海200241 [3]华中农业大学动物医学院,武汉430070 [4]中国农业大学动物医学院,北京100193 [5]中国食品药品检定研究院,北京100050

出　　处：《实验动物科学》2022年第5期31-36,共6页Laboratory Animal Science

基　　金：ANGPTL3-MYCBP融合基因在肝癌中的功能及作用机制研究(GDXZ2022008);干扰素调节因子2(IRF2)在脂肪细胞分化中的作用及机制研究(GDXZ2022009)。

摘　　要：目的 探究猫血液生理生化指标的范围以及性别因素和年龄因素对于机体生理生化指标的影响。方法 从武汉市招募家猫作为研究对象,采用完全随机法筛选出75只猫,采集血液检测血细胞计数和血液生化指标,并进行统计学分析。结果 初步明确了猫的血细胞计数指标和血生化指标的范围,并发现性别因素对猫生理生化指标中的天门冬氨酸转氨酶有影响(P<0.05),其他指标均无显著影响(P>0.05)。年龄因素对于猫血细胞计数指标和血生化指标具有明显的影响:其中白细胞、单核细胞、中性粒细胞计数随着年龄的增长呈降低趋势;红细胞比容、红细胞平均血红蛋白浓度随着年龄增长呈增高趋势;血生化中的磷、钙离子随着年龄的增加呈下降的趋势,肌酐、胆固醇、随机血糖、球蛋白等指标随着年龄的增长呈上升趋势。结论 本研究初步探索了猫生理生化指标的正常范围,发现猫血生理生化指标受年龄因素影响较为显著,为推进猫作为实验动物提供了依据;同时,本研究提示不同年龄阶段的猫对营养需求具有差异性,为对猫的精准饲喂和健康护理提供理论指导。Objective The purpose of this investigation is to explore the range of blood physiological and biochemical indicators of healthy cats(in good condition without reported disease history), and the influence of factors including gender and age on these indicators, further to promote the standardization of cats as experimental animals.Method Domestic cats were recruited from Wuhan city as the research subjects, and 75 healthy cats were screened by completely random method. Blood was collected to detect blood cell count and blood biochemical indicators. Then statistical analysis was performed.Result The range of blood cell count indexes and blood biochemical indexes of healthy cats were preliminarily clarified. It was found that the blood cell count and most physiological and biochemical indexes excluding AST(P<0.05) were not significantly influenced by age but not gender of cats. The white blood cell, monocyte, and neutrophil counts had a decrease tendacy with age. Contrarily, hematocrit and average hemoglobin concentration in red blood cells were all increased with age. As the age increasing, the concentration of phosphorus and calcium ions in blood showed a downward trend, while the indicators such as creatinine, cholesterol, globulin and random blood sugar showed an upward trend.Conclusion This study preliminarily explored the normal range of cat’s blood physiological and biochemical indicators, and found that theses indicators were significantly affected by aging. The result provided a basis for promoting cats as standard experimental animals. Meanwhile, this study suggests that cats of different ages have different nutritional needs, providing theoretical guidance for precision feeding and health care for cats.

关 键 词：猫 实验动物 血细胞计数 血生化 范围 

分 类 号：Q95-3[生物学—动物学]