实验外科复杂手术中巴马猪超长时间复合麻醉方案探索  

Exploration of Bama Pig Ultra-long Time Combined Anesthesia in Complicated Operation of Experimental Surgery

作　　者：彭旭 尹海林 PENG Xu;YIN Hailin(Laboratory Animal Centre,Sichuan University,Chengdu 610065,China)

机构地区：[1]四川大学实验动物中心,成都610065

出　　处：《实验动物科学》2022年第5期37-44,共8页Laboratory Animal Science

摘　　要：目的 探索巴马猪超过6 h的复合麻醉方案用于实验外科复杂手术的有效性。方法 将舒泰、多咪静、异氟烷、布托啡诺4种主药联合使用麻醉巴马猪,用于国产某手术机器人进行的单肾摘除并肾静脉阻断后原位移植、深部直肠切除并吻合、胰腺切除+脾脏摘除+胃穿孔吻合等时间长的复杂手术,于整个手术过程监测巴马猪生命体征,以及镇静、镇痛、肌松效果,结合死亡病例进行分析,以评估该方案在手术过程中的麻醉效果。结果 1头巴马猪因低血容量性休克死亡,其余12头巴马猪顺利完成超过6 h的腹腔手术,术中无不良反应,心率、血氧饱和度、平均动脉压、体温监测值均在正常范围内波动。结论 本麻醉方案能确保巴马猪的麻醉时间达到6 h以上,能保证手术机器人完成腹腔内脏摘除、血管剥离并吻合、组织切割与缝合等操作,术中麻醉平稳,镇静镇痛效果优异,术后苏醒快,且4种主要麻醉药均为兽用,首次使用后保存时间较长,完全能满足实验外科超长时间复杂手术各项要求。Objective Explore a combined anesthesia more than 6 hours for Bama pigs and explore the effectiveness of complicated surgical procedures used in experimental surgery.Method Combining four main medicines: Zoletil, Dexdomitor, Isoflurane, Butorphanol to perform single kidney removal and orthotopic transplantation after renal vein occlusion, deep rectal resection and anastomosis, pancreatic resection + spleen removal + gastric perforation anastomosis. Monitor the vital signs of Bama pigs, as well as sedative, analgesic, and muscle relaxation effects during the entire anesthesia process, and also analysis combined with death cases to evaluate the anesthetic effect of the program.Result 1 Bama pig died of hypovolemic shock, the rest of 12 Bama pigs successfully completed more than 6 hours abdominal surgery, no adverse reactions. Heart rate, blood oxygen saturation, mean arterial pressure, body temperature were stable, and both fluctuate within the normal range.Conclusion This anesthesia program can ensure the anesthesia time of the Bama pig exceed 6 hours, and can successfully complete the operations of abdominal organ removal, blood vessel dissection and anastomosis, tissue cutting and suture by surgical robot. During the operation, the anesthesia is stable, the effect of sedation and analgesia is excellent, pigs wake up quickly post-operation. The four main anesthetics are veterinary drugs, and the storage time is longer after the first use, which fully meets the requirements of experimental surgery for extra-long time and complicated operations.

关 键 词：巴马猪 复杂手术 复合麻醉 超长时间 实验外科 

分 类 号：Q95-3[生物学—动物学]