中医药改善三阴性乳腺癌术后患者生活质量临床观察  

Clinical observation of traditional Chinese medicine in improving the quality of life of patients with triple-negative breast cancer after surgery

作　　者：张佳慧 于明薇[1] 王笑民[1] 孟慧[2] 陈星 丁彤晶 周杰[1] 高宠 ZHANG Jiahui;YU Mingwei;WANG Xiaomin;MENG Hui;CHEN Xing;DING Tongjing;ZHOU Jie;GAO Chong(Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University,Beijing 100010,China;Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京中医医院,北京100010 [2]北京中医药大学

出　　处：《北京中医药大学学报》2022年第11期1095-1102,共8页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(No.82004289);北京市自然科学基金项目(No.7202065);北京市科技计划项目(No.D161100005116005,No.Z191100008319006)。

摘　　要：目的 观察中医药改善三阴性乳腺癌术后放射治疗、化学药物治疗后患者生活质量的临床疗效。方法 2016年3月—2017年12月,根据纳入、排除标准从首都医科大学附属北京中医医院等9家北京三甲医院收入314例患者,中医组(198例)辨证论治服用中药,观察组(116例)不接受与三阴性乳腺癌相关的中医药治疗,每3~6个月对所有患者进行一次随访,直至完成3年随访。根据针对乳腺癌患者的生活质量量表、医院焦虑抑郁量表、Piper疲乏量表中文版和匹兹堡睡眠质量指数评价患者的生活质量。结果 中医组针对乳腺癌患者的生活质量量表总评分及生理状况、情感状况、功能状况及附加关注评分改善程度均大于观察组(P<0.05,P<0.01)。中医组医院焦虑抑郁量表中焦虑和抑郁评分改善程度均大于观察组(P<0.01)。中医组Piper疲乏量表中文版总评分及子维度行为、情绪、感觉、认知评分的改善程度均大于观察组(P<0.01)。匹兹堡睡眠质量指数总评分及各子维度评分改善程度组间差异均无统计学意义。结论 中医药治疗可改善三阴性乳腺癌患者疲乏程度,缓解焦虑抑郁情绪,提高整体的生活质量,且药物安全性良好。Objective To observe the clinical effect of traditional Chinese medicine in improving the quality of life of patients with triple-negative breast cancer after radiotherapy and chemotherapy.Methods From March 2016 to December 2017, according to the admission and discharge criteria, 314 patients were collected from nine tertiary hospitals in Beijing, including Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University. The traditional Chinese medicine group(198 cases) received traditional Chinese medicine based on syndrome differentiation, while the observation group(116 cases) did not receive traditional Chinese medicine treatment related to triple-negative breast cancer. All of the patients were followed up every 3-6 months until the 3-year follow-up was completed. The patients’ quality of life was evaluated according to the Functional Assessment of Cancer Therapy-Breast(FACT-B), the Hospital Anxiety and Depression Scale(HADS), the Chinese version of Piper Fatigue Scale, and the Pittsburgh sleep quality index.Results The improvement degree of the total score of FACT-B and the scores of physiological condition, emotional state, functional status and additional concerns in the traditional Chinese medicine group were higher than those in the observation group(P<0.05, P<0.01). The degree of improvement of anxiety and depression scores in HADS in the traditional Chinese medicine group was higher than that of the observation group(P<0.01). The improvement in the total score and sub-dimensions of behavior, emotion, feeling and cognition of the Chinese version of Piper Fatigue Scale in the traditional Chinese medicine group were higher than those of the observation group(P<0.01). There was no significant difference between the two groups in terms of the improvement in the total score and each sub-dimension score of the Pittsburgh sleep quality index.Conclusion Chinese medicine treatment can improve the degree of fatigue, relieve anxiety and depression in patients with triple-negative brea

关 键 词：中医药 三阴性乳腺癌 疲乏 失眠 焦虑 抑郁 生活质量 

分 类 号：R273[医药卫生—中西医结合]