云南拉祜族人群ABO、Rh、MN、P、H血型分布及基因频率调查  

Distribution of ABO, Rh, Mn, P, h blood groups and gene frequency in Lahu ethnic minority in Yunnan

作　　者：胡海霞 方成江 吴丹 吴瑜 王晨[2] 王中英[2] 张玉宇 向东[2] 张正荣 HU Haixia;FANG Chengjiang;WU Dan;WU Yu;WANG Chen;WANG Zhongying;ZHANG Yuyu;XIANG Dong;ZHANG Zhenrong(Puer Blood Center,Puer 665000,China;Shanghai Blood Center;Puer People's Hospital)

机构地区：[1]普洱市中心血站,云南普洱665000 [2]上海血液中心 [3]普洱市人民医院

出　　处：《中国输血杂志》2022年第10期1059-1061,共3页Chinese Journal of Blood Transfusion

摘　　要：目的了解拉祜族人群主要红细胞血型分布及基因频率,分析拉祜族人群的遗传特征。方法1)用微板法进行ABO正反定型;2)试管法对Rh、MN、H、P、Mur进行检测分型,ABO正反定型不符用试管法确认。结果拉祜族血型及基因频率分布特征:ABO为B>O>A>AB、基因型频率p=11.1%;q=27.5%;r=61.4%;RH基因型频率为CDe=83.3%;cDE=12.0%;cDe=2.42%;CDE=2.32%;CdE=0%;Cde=0%;cdE=0%;cde=0%;MN血型:M>MN>N,M=75.26%,N=24.74%;P1Pk血型:P_(1)<P_(2);基因频率为P_(1)=9.65%、P_(2)=90.35%;在588个拉祜族人中检出4例类孟买血型,表现频率为0.68%。结论云南普洱拉祜族人群红细胞血型分布具有北方民族特征,其H抗原阴性的表型频率0.68%,具明显的地域和民族特异性。Objective To understand the distribution and gene frequency of main red blood cell blood groups in Lahu ethnic minority and analyze the genetic characteristics of Lahu people.Methods 1)ABO forward and reverse typing had been performed by microplate method;2)Rh,MN,H,P1 Pk and Mur antigen were tested by the tube method.If the ABO forward and reverse typing were incompatible,the tube method was used for confirmation.Results The distribution characteristics of blood group and gene frequency in Lahu ethnic minority were as follows:B>O>A>AB for ABO,with genotype frequency as p 11.1%,q 27.5%and r 61.4%;the frequency of Rh genotype was CDe 83.3%,cDE 12.0%,cDe 2.42%,CDE 2.32%,CdE 0%,Cde 0%,cdE 0%and cde 0%;M>MN>N for MN blood group,with genotype frequency as M 75.26%and N 24.74%;P1<P2 for P1Pk blood group,with gene frequencies as P1 9.65%and P2 90.35%;Four para-Bombay cases were detected out of 588 Lahu individuals,with a frequency of 0.68%,presenting obvious regional and ethnic characteristics.Conclusion The distribution of red blood cell blood group of Lahu people in Pu'er has the characteristics of northern nationalities.The phenotypic frequency of negative H antigen is 0.68%,which has obvious regional and ethnic characteristics.

关 键 词：云南 拉祜 ABO RH MN P H血型 基因频率 

分 类 号：R457.11[医药卫生—治疗学]