中药调控小胶质细胞改善阿尔茨海默病的研究进展  

Advance in Traditional Chinese Medicine for Alzheimer′s disease by regulating microglia

作　　者：潘予璠 信琪琪 袁蓉[2] 缪宇[2] 丛伟红[2] PAN Yu-fan;XIN Qi-qi;YUAN Rong;MIAO Yu;CONG Wei-hong(Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Lab of Cardiovascular Diseases,Xiyuan Hospital of China Academy of Chinese Medical Sciences,National Clinical Research Center for Chinese Medicine Cardiology,Beijing 100091,China)

机构地区：[1]天津中医药大学研究生院,天津301617 [2]中国中医科学院西苑医院心血管病实验室,国家中医心血管病临床医学研究中心,北京100091

出　　处：《中国药理学通报》2023年第2期207-211,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81373821);中国博士后科学基金资助项目(No 2014M550134);人社部归国留学人员择优资助项目。

摘　　要：小胶质细胞(microglia,MG)作为中枢神经系统的主要免疫巨噬细胞,可通过不同极化状态和受体蛋白表达水平参与阿尔茨海默病(Alzheimer′s disease,AD)的发生、发展过程。传统中药对小胶质细胞具有调控作用,中药所含多种成分在减少淀粉样蛋白(amyloidβ-protein,Aβ)沉积、抑制神经炎症以及调控MG极化等方面可发挥重要作用。该文对MG在AD发病机制中的作用以及中药调控MG的作用和机制进行总结和分析,旨在为中药治疗AD提供参考。Microglia,the main immune macrophages in the central nervous system,can be highly involved in the occurrence and development of Alzheimer′s disease(AD)through microglia polarization and receptor protein expression.Traditional Chinese Medicine has been demonstrated to have regulatory effects on MG.Many active components in Traditional Chinese herbs play important roles in decreasingβ-amyloid peptide(Aβ)accumulation,inhibiting neuro-inflammation and regulating microglia polarization etc.In this study the role of microglia in the pathogenesis of AD and the mechanism by which Traditional Chinese Medicine regulating microglia are reviewed to provide a reference for the treatment of AD.

关 键 词：小胶质细胞 阿尔茨海默病 中药 淀粉样蛋白沉积 神经炎症 作用机制 

分 类 号：R282.71[医药卫生—中药学] R322.81[医药卫生—中医学] R341R364.5R745.71