“血管-免疫交联”策略在肿瘤治疗中的研究进展  

Advances of immune-vascular crosstalk for oncology therapeutics

作　　者：毛登烜 赵杨[3] 刘玉萍 陈彦[1,2] MAO Deng-xuan;ZHAO Yang;LIU Yu-ping;CHEN Yan(Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine;Multi-component of Traditional Chinese Medicine and Microecology Research Center,Jiangsu Provincial Academy of Chinese Medicine,Nanjing 210028,China;School of Medicine&Holistic Integrative Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学附属中西医结合医院 [2]江苏省中医药研究院,中药组分与微生态研究中心,江苏南京210028 [3]南京中医药大学,医学院•整合医学学院,江苏南京210023

出　　处：《中国药理学通报》2023年第2期212-218,共7页Chinese Pharmacological Bulletin

基　　金：江苏省中医药科技发展专项(No 2020ZX15);国家自然科学基金资助项目(No 81903858)。

摘　　要：恶性肿瘤是目前威胁人类健康安全的重要原因之一,抗血管生成药物和免疫检查点抑制剂的应用为肿瘤治疗带来了希望,然而肿瘤血管与免疫微环境之间相互交错的复杂关系导致其疗效不如人意。散乱的肿瘤血管阻碍CD8^(+)T细胞进入肿瘤微环境,而且肿瘤血管生成的关键驱动力VEGF干扰树突状细胞的成熟,从而抑制T细胞的启动,VEGF还诱导CD8^(+)T细胞的耗竭。同时,多种先天免疫细胞和获得性免疫细胞分泌促血管生成因子,加速失控的血管生成,促进血管不成熟。因此,靶向肿瘤血管和免疫是加强肿瘤免疫治疗的一种有潜力的策略。近年来,大量研究发现运用血管与免疫相互干预的策略来进行联合抗肿瘤免疫治疗取得了很好的效果。该综述对免疫和血管交联肿瘤微环境进行总结与讨论,综述了近几年内运用血管-免疫相互干预策略治疗肿瘤的研究进展,为进一步提高肿瘤免疫治疗的疗效提供参考。Malignant tumor is one of the important reasons threatening human health and safety at present.The application of antiangiogenic drugs and immune checkpoint inhibitors has brought great hope for tumor treatment,but the complex interlaced relationship between tumor blood vessels and immune microenvironment leads to unsatisfactory efficacy.In addition,VEGF,a key driver of tumor angiogenesis,interferes with the maturation of dendritic cells,thereby inhibiting the initiation of T cells.VEGF also induces depletion of CD8^(+)T cells.At the same time,various innate and acquired immune cells secrete angiogenic factors that accelerate uncontrolled angiogenesis and promote vascular immaturity.Therefore targeting tumor blood vessels and immunity is a potential strategy for enhancing tumor immunotherapy.In recent years numerous studies have found that using the blood vessels and the immune intervention strategies combined with antitumor immune therapy has achieved good results.In this review the immune and vascularized tumor microenvironment are reviewed and discussed,and the research progress of vascularized immune interintervention strategy for tumor treatment in recent years is reviewed so as to provide reference for further improving the efficacy of tumor immunotherapy.

关 键 词：肿瘤 免疫 血管 交联作用 

分 类 号：R322.12[医药卫生—人体解剖和组织胚胎学] R364.3[医药卫生—基础医学] R392.12R730.51