免疫细胞来源的外泌体在结直肠癌中的研究进展  

Research progress of immune cell-derived exosomes in colorectal cancer

作　　者：杨健 盛康亮 王永中[1] YANG Jian;SHENG Kang-liang;WANG Yong-zhong(School of Life Sciences,Anhui University,Key Laboratory of Human Microenvironment and Precision Medicine of Anhui Higher Education Institutes,Anhui University,Hefei 230601,China)

机构地区：[1]安徽大学生命科学学院,安徽省人体微生态与精准医药重点实验室,安徽合肥230601

出　　处：《中国药理学通报》2023年第2期224-228,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 32000081,31770066);安徽省自然科学基金资助项目(No 1908085QC120);安徽省高校研究科研项目(No YJS20210039);安徽大学博士科研启动基金资助项目(No J01003316)。

摘　　要：外泌体是一种携带蛋白质、RNA、脂质等生物活性物质的囊泡样小体,由胞内向胞外分泌,作用于靶细胞而发挥其生物学功能。结直肠癌是恶性肿瘤之一,其发病率和死亡率均较高。研究发现,免疫细胞来源的外泌体参与调控结直肠癌的生长、侵袭、转移等过程,且在肿瘤的诊断、治疗以及治疗后监测等方面表现出明显的作用。该文将对免疫细胞来源的外泌体在结直肠癌中的研究进展作一综述。Exosomes are vesicle-like bodies carrying proteins,RNA,lipids and other bioactive substances,which are secreted from intracellular to extracellular and act on target cells to play their biological functions.Colorectal cancer is one of the malignant tumors with high morbidity and mortality.It has been found that immune cell-derived exosomes participate in the regulation of colorectal cancer growth,invasion,metastasis and other processes.It also plays an obvious role in tumor diagnosis,treatment and post-treatment monitoring.In this review we summarize the research progress of immune cell-derived exosomes in colorectal cancer.

关 键 词：外泌体 免疫细胞 结直肠癌 免疫调节 研究进展 微小核糖核酸 

分 类 号：R342.2[医药卫生—基础医学] R392.11R392.12R735.35