定量SPECT探头系统平面灵敏度测试影响因素分析  

Influencing Factors Analysis of System Planar Sensitivity Test in Quantitative SPECT

作　　者：张青菊 惠金子 许建林 施常备 杨胜利 南永刚 ZHANG Qingju;HUI Jinzi;XU Jianlin;SHI Changbei;YANG Shengli;NAN Yonggang(Department of Nuclear Medicine,Shaanxi Provincial Cancer Hospital,Xi’an Shaanxi 710061,China;Department of Medical Examination,Shaanxi Provincial Cancer Hospital,Xi’an Shaanxi 710061,China)

机构地区：[1]陕西省肿瘤医院核医学科,陕西西安710061 [2]陕西省肿瘤医院体检科,陕西西安710061

出　　处：《中国医疗设备》2023年第1期53-57,64,共6页China Medical Devices

基　　金：陕西省肿瘤医院国家自然科学基金孵育项目(SC212016)。

摘　　要：目的比较手动测量及设备指导式测量单光子发射断层成像仪(Single Photon Emission Computed Tomography,SPECT)系统平面灵敏度的结果,分析面源与准直器距离、面源直径及面源活度在一定范围内波动对测试结果的影响,以指导定量SPECT质量控制。方法用手动测量及设备指导式测量2种方法分别按标准条件、面源与准直器的距离不同、面源直径不同、面源活度不同的条件对GE Discovery 670Pro SPECT进行系统平面灵敏度测试,记录结果及相应采集时长。采用Bland Altman分析2种方法测量结果的一致性;用单样本Wilcoxon符号秩和检验分析不同测试条件下,系统平面灵敏度测试结果及采集时长与标准条件下测试结果及采集时长的差异。结果标准条件下手动测量及设备指导式测量SPECT系统平面灵敏度结果分别为166.73、168.50 counts/min/μCi,采集时长分别为9.18、8.93 min。手动测量及设备指导式测量结果一致性良好,全部点位于95%一致性界限内。面源与准直器距离介于5~20 cm,面源直径介于3.5~20.0 cm时,2种方法测量系统平面灵敏度结果与标准条件下测试结果无显著差异(P>0.05),采集时间与标准条件下的无显著差异(P>0.05);面源活度不同时,2种方法测量系统平面灵敏度结果与标准条件下测试结果亦无显著差异(P=0.086、0.593),但采集时长较标准条件下的差异较大(P=0.046、0.039),其中面源活度介于18.5~74.0 MBq时,采集时长介于47.69~11.57 min,面源活度介于92.5~222.0 MBq时,采集时长均小于10 min,且采集时长缩短趋势平缓。结论手动测量及设备指导式测量SPECT系统平面灵敏度结果一致性良好,测试条件可参照相关要求在一定范围内波动。Objective To compare the results of system planar sensitivity tested by manual measurement and equipment-guided measurement in quantitative single photon emission computed tomography(SPECT),to analyze the influence to the results of system planar sensitivity when the distance between the planar source and the collimator,the diameter of the planar source and the activity of the planar source fluctuated within a certain range,so as to guide the quality control test of SPECT.Methods The system planar sensitivity of GE Discovery 670Pro SPECT was tested by manual measurement and equipment-guided measurement under standard conditions,the distance between the planar source and the collimator,the diameter of the planar source and the activity of the planar source,the corresponding acquisition time was recorded.Bland Altman was used to analyze the consistency of the two methods.The diferences between the results of system planar sensitivity and acquisition time tested under diferent conditions and which tested under standard conditions were analyzed using the single-sample Wilcoxon rank sum test.Results The results of system planar sensitivity of SPECT tested by manual measurement and equipment-guided measurement were 166.73,168.50 counts/min/μCi under standard conditions,the corresponding acquisition time were 9.18,8.93 min.The results tested by the two methods were in good consistency,all points were located inside 95%limit of agreement.There was no significant diference among the planar sensitivity results when the distance between the planar source and the collimator were 5-20 cm and the diameter of the planar source were 3.5-20.0cm,there was no significant diference between the planar sensitivity results of the two methods and the standard conditions(P>0.05),and the acquisition time had no significant differences with which tested under standard conditions(P>0.05).When the planar source activity was diferent,there was no significant diference between the the planar sensitivity results of the two methods and the stan

关 键 词：定量单光子发射断层成像仪/定量SPECT 质量控制 系统平面灵敏度 影响因素 

分 类 号：R197.39[医药卫生—卫生事业管理]