庆阳市献血人群丙型肝炎病毒感染检测与特征研究  

Detection and Characteristics of Hepatitis C Virus Infection among Blood Donors in Qingyang City

作　　者：张小霞 韩亚鹏[2] ZHANG Xiao-Xia;HAN Ya-Peng(Central Blood Station of Qingyang,Qingyang 745000,Gansu Province,China;Provincial Key Laboratory for Protection and Utilization of Longdong Bio-resources in Gansu Province,Longdong University,Qingyang 745000,Gansu Province,China)

机构地区：[1]庆阳市中心血站,甘肃庆阳745000 [2]甘肃省陇东生物资源保护利用与生态修复重点实验室,陇东学院,甘肃庆阳745000

出　　处：《中国实验血液学杂志》2022年第6期1856-1860,共5页Journal of Experimental Hematology

基　　金：庆阳市科技计划资助项目(QY2021A-S018,QY2021A-F015)。

摘　　要：目的:了解庆阳市献血人群丙型肝炎病毒(HCV)的流行现状,降低HCV经血传播的风险。方法:对庆阳市无偿献血者HCV筛查中应用核酸及酶免检测技术进行对比分析,研究阳性人群特征与合并感染状况。结果:2015-2020年庆阳市献血人群HCV检测阳性率为3.2‰;酶免HCV阳性合并感染中,合并梅毒螺旋体最多,其次为合并丙氨酸氨基转移酶、乙型肝炎病毒表面抗原阳性;动员方式以个人自愿为主;主要年龄段为26-45岁;血型分布显示,B型31.08%,O型28.31%,A型27.38%,AB型13.23%,AB型人群低于B型、O型人群;性别分布显示,男性多于女性;婚姻状况集中在已婚人群中;区域分布集中在西峰区,庆城县高于华池县和外地,宁县、合水县、镇原县和环县等地接近;职业以其他无业人员为主;民族均为汉族。本市青年志愿者的丙型肝炎病毒知识总体知晓率为67.2%。结论:无偿献血者HCV感染人群合并梅毒螺旋体感染较多,青年志愿者对丙型肝炎病毒知识的认知水平有待提升。Objective:To deeply understand the epidemic status of hepatitis C virus(HCV)among blood donors in Qingyang City,and prevent the risk of transmission of HCV via blood.Methods:To compare the application of nucleic acid and enzyme immunoassay adopted in HCV screening of volunteer blood donors in Qingyang City.The characteristics of positive population and the status of co-infection were studied.Results:From 2015 to 2020,the positive rate of HCV detection among blood donors in Qingyang City was 3.2‰.Among the HCV positive co-infections,treponema pallidum(TP)accounted for the largest proportion,followed by alanine aminotransferase(ALT)and HBsAg.Blood donation was mainly based on individual voluntariness,and the main age group was 26-45 years old.The distribution of blood type showed that 31.08%for type B,28.31%for type O,27.38%for type A and 13.23%for type AB,the population of type AB was lower than that of type B and type O.The distribution of sex showed that male was more than female.The marital status was concentrated in married population.The regional distribution was concentrated in Xifeng District.Qingcheng County was higher than Huachi County and other places,while Ning County,Heshui County,Zhenyuan County and Huan County were close.The occupation was dominated by unemployed.Their nationalities were all Han.The overall awareness rate of HCV knowledge in young volunteers was 67.2%.Conclusion:There are more HCV infected people with TP infection in voluntary blood donors,and the cognitive level of HCV knowledge in young volunteers needs to be improved.

关 键 词：无偿献血者 丙型肝炎病毒 合并感染 

分 类 号：R512.63[医药卫生—内科学]