益肾结透汤序贯结肠透析模式对慢性肾脏病患者微炎症状态及肾功能的影响  

Effect of sequential colon dialysis mode of Yishen Jietou Decoction on the micro inflammatory state and renal function in patients with chronic kidney disease

作　　者：邬政付 李正胜 毕莲 谢娟 张雄峰 王治义 WU Zhengfu;LI Zhengsheng;BI Lian;XIE Juan;ZHANG Xiongfeng;WANG Zhiyi(Department of Nephrology,the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550001,China;Medical Department of the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550001,China)

机构地区：[1]贵州中医药大学第二附属医院肾内科,贵阳550001 [2]贵州中医药大学第一附属医院医务科,贵阳550001

出　　处：《吉林中医药》2023年第1期57-60,共4页Jilin Journal of Chinese Medicine

基　　金：贵州省贵阳市科技计划项目(筑科合同[2019]-9-4-7号)。

摘　　要：目的观察益肾结透汤序贯结肠透析模式对慢性肾脏病(CKD)患者微炎症状态及肾功能的影响。方法选择160例慢性肾脏病患者,采用随机数表法分为结透组、中药组、序贯组及安慰剂组,各40例。结透组予结肠透析治疗,隔日1次;中药组予益肾结透汤中药保留灌肠,隔日1次;序贯组予结肠透析联合益肾结透汤中药保留灌肠治疗,隔日1次;安慰剂组予结肠透析联合生理盐水保留灌肠,隔日1次。治疗8周后观察4组治疗前后微炎症及肾功能指标变化情况,分析益肾结透汤序贯结肠透析模式对慢性肾脏病患者微炎症状态及肾功能的影响。结果4组治疗后hs-CRP、IL-6、BUN、Scr、CYS-C较治疗前均显著降低(P<0.05);结透组、中药组、安慰剂组治疗后β2-MG与治疗前比较,差异无统计学意义(P>0.05),序贯组治疗后β2-MG较治疗前显著降低(P<0.05)。治疗后4组间比较,结透组、中药组及安慰剂组治疗后hs-CRP、IL-6、BUN、Scr、CYS-C、β2-MG组间比较,差异无统计学意义(P>0.05),序贯组治疗后hs-CRP、IL-6、BUN、Scr、CYS-C、β2-MG均低于其他3组(P<0.05)。结论益肾结透汤序贯结肠透析模式能显著改善慢性肾脏病患者微炎症状态及肾功能,且疗效优于单纯结肠透析及单纯中药保留灌肠治疗模式。Objective To observe the effect of the sequential colon dialysis mode of Yishen Jietou Decoction on the micro inflammatory state and renal function in patients with chronic kidney disease(CKD).MMeetthhooddss A total of 160patients who met the inclusion criteria in the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine from December 2019 to December 2021 were randomly divided into four groups:the colon dialysis group,the traditional Chinese medicine group,the sequential group and the placebo group,with 40 cases in each group.The colon dialysis group was treated with colon dialysis once every other day.The traditional Chinese medicine group was given traditional Chinese medicine retention enema of Yishen Jietou Decoction once every other day.The sequential group was treated with colon dialysis combined with traditional Chinese medicine retention enema of Yishen Jietou Decoction,once every other day.The placebo group was given colon dialysis combined with normal saline retention enema once every other day.After 8 weeks of treatment,the changes of micro inflammation and renal function indexes in the four groups were observed before and after treatment,and the effects of the sequential colon dialysis mode of Yishen Jietou Decoction on the micro inflammation and renal function in patients with CKD were analyzed.Results After treatment,the levels of hs-CRP,IL-6,BUN,Scr and CYS-C in the four groups were significantly lower than those before treatment(P<0.05).There was no significant difference in the level ofβ2-MG in the colon dialysis group,traditional Chinese medicine group and placebo group compared with before treatment(P>0.05),but the level ofβ2-MG after treatment in the sequential group was significantly lower than that before treatment(P<0.05).After treatment,there was no significant difference in the levels of hs-CRP,IL-6,BUN,Scr,CYS-C andβ2-MG between the colon dialysis group,traditional Chinese medicine group and placebo group(P>0.05),while the sequential group was significantly

关 键 词：结肠透析 中药保留灌肠 慢性肾脏病 益肾结透汤 

分 类 号：R459.9[医药卫生—治疗学]