内分泌科住院患者多重耐药菌感染及抗生素使用情况  

Multi-drug resistant bacteria infection and antibiotic use in inpatients in endocrinology department

作　　者：韩博[1] 石露露 欧学兰 张双红 赵育林 HAN Bo;Shi Lu-lu;OU Xue-lan;ZHANG Shuang-hong;ZHAO Yu-lin(Zhangjiakou University,zhangjiakou075000,Hebei,China;Zhangjiakou First Hospital)

机构地区：[1]张家口学院,河北张家口07500 [2]张家口市第一医院

出　　处：《中国病原生物学杂志》2022年第12期1446-1449,共4页Journal of Pathogen Biology

摘　　要：目的 研究内分泌科住院患者多重耐药菌感染及抗生素使用情况,为内分泌科患者感染预防和治疗提供依据。方法 收集内分泌科收治的1 183例患者临床资料。对病原菌进行培养、鉴定,同时K-B纸片扩散法对病原菌进行药敏试验。结果 1183例内分泌科住院患者中,153例患者发生院内感染,感染率为12.93%。其中150例患者为单一病原菌感染,3例患者为双重病原菌感染。共计分离出156株病原菌,其中革兰阴性菌93株,革兰阳性菌63株。多耐药检出56株,占检出病原菌总数35.90%。大肠埃希菌对头孢他啶、头孢吡肟、哌拉西林、哌拉西林-他唑巴坦、左氧氟沙星、庆大霉素、阿米卡星、美罗培南和亚胺培南耐药率为35.56%、26.67%、62.22%、6.67%、6.67%、33.33%、4.44%、2.22%和2.22%。金黄色葡萄球菌对青霉素、红霉素、四环素、头孢呋辛酯、头孢噻肟、左氧氟沙星、哌拉西林、头孢吡肟、庆大霉素、阿米卡星和利福平耐药率为80.77%、73.08%、61.54%、42.31%、38.46%、34.62%、42.31%、11.54%、19.23%、3.85%和30.77%,对万古霉素和替考拉宁未产生耐受性。不同样本多重耐药菌分离情况:尿液、痰液、消化道、分泌物以及血液中分离的多重耐药菌分别为28、16、5、5和2株,分别占50.00%、28.57%、8.93%、8.93%和3.57%。2018-2021年内分泌科住院患者多重耐药菌感染率为4.27%、4.30%、4.39%和5.26%,抗生素使用率为19.93%、22.52%、22.30%、24.01%和22.23%。结论 患者多重耐药菌感染率随抗生素使用率上升。内分泌科住院患者多重耐药菌感染类型以革兰氏阴性菌为主,其中大肠埃希菌居多。Objective The multi-drug resistant bacteria infection and distribution in inpatients in endocrinology department were analyzed for providing basis for the prevention and treatment clinical anti-infection.Methods Clinical data of 1 183 cases o f patients were collected.The pathogenic bacteria were cultured and identified,and the drug sensitivity of the pathogenic bacteria was tested by K-B disk diffusion method.Results Among 1 183 inpatients in endocrinology department,153 patients had nosocomial infection,and the infection rate was 12.93%.Among them,150 patients were single pathogen infection and 3 patients were double pathogen infection.A total of 156 strains of pathogens were isolated,including 93 strains of Gram-negative bacteria and 63 strains of Gram-positive bacteria.56 strains of multidrug resistance were detected,accounting for 35.90% of the total pathogens.The resistance rates of Escherichia coli to ceftazidime,cefepime,piperacillin,piperacillin tazobactam,levofloxacin,gentamicin,amikacin,meropenem and imipenem were 35.56%,26.67%,62.22%,6.67%,6.67%,33.33%,4a.44%,2.22% and 2.22%.The resistance rates of Staphylococcus aureus to penicillin,erythromycin,tetracycline,cefuroxime axetil,cefotaxime,levofloxacin,piperacillin,cefepime,gentamicin,amikacin and rifampicin were 80.77%,73.08%,61.54%,42.31%,38.46%,34.62%,42.31%,11.54%,19.23%,3.85% and 30.77%,and there was no tolerance to vancomycin and teicoplanin.Isolation of multidrug-resistant bacteria from differents amples:28 strains,16 strains,5 strains,5 strains and 2 strains were isolated from urine,sputum,digestive tract,secretion and blood,accounting for 50.00%,28.57%,8.93%,8.93% and 3.57% respectively.From 2018 to 2021,the infection rates of multidrug-resistant bacteria in inpatients in endocrinology department were 4.27%,4.30%,4.39% and 5.26%,and the use rates of antibiotics were 19.93%,22.52%,22.30%,24.01% and 22.23%.Conclusion The infection rate of multi drug resistant bacteria increased with the use of antibiotics.The infection types of multi-drug resista

关 键 词：内分泌科 住院患者 多重耐药菌感染 

分 类 号：R378[医药卫生—病原生物学]