分枝杆菌诱导宿主免疫细胞凋亡机制的研究进展  

Research progress on the mechanism of Mycobacterium inducing apoptosis of host immune cells

作　　者：丁寿鹏 王国富 吴利先 DING Shou-peng;WANG Guo-fu;WU Li-xian(Department of Microbiology and Immunology,School of Basic Medical Sciences,Dali University)

机构地区：[1]大理大学基础医学院医学微生物与免疫教研室,云南大理671000

出　　处：《中国病原生物学杂志》2022年第12期1480-1483,共4页Journal of Pathogen Biology

基　　金：国家自然科学基金项目(No.81760357)。

摘　　要：鸟结核分枝杆菌(Mycobacterium avium tuberculosis,MAV)是引起严重机会性肺病的重要病原体之一。对于免疫功能低下的患者,例如合并HIV感染者,MAV是严重的晚期并发症。目前,MAV与免疫细胞间作用机制尚不清楚。MAV主要寄生于巨噬细胞中,因此了解其对巨噬凋亡的诱导机制极其上游调控基因对未来寻找有效的治疗手段尤为重要。本文将对MAV诱导巨噬细胞及其他免疫细胞凋亡的机制进行综述。Mycobacterium avium tuberculosis(MAV) is one of the major causes of severe opportunistic lung disease.In immunocompromised patients,such as those with HIV,MAV is a serious late complication.Currently,the mechanism of apoptosis induced by MAV is poorly understood.MAV is only parasitic in macrophages,so understanding the mechanism of apoptosis induced by MAV on macrophages is very important for finding effective treatment in the future.In this review,we will review the mechanism of MAV induced apoptosis of macrophages and other immune cells.

关 键 词：MAV 巨噬细胞 免疫细胞 细胞因子 综述 

分 类 号：R378.911[医药卫生—病原生物学]