体外代谢技术在毒品检验中的应用进展  

Progress on the Application of in Vitro Metabolism in Illicit Drug Identification

作　　者：明珠 陈学国[1] 周艳 杜瑞轩 王丹[1] MING Zhu;CHEN Xueguo;ZHOU Yan;DU Ruixuan;WANG Dan(Forensic Science School of Criminal Investigation Police University of China,Shenyang 110035,Liaoning,China)

机构地区：[1]中国刑事警察学院刑事科学技术学院,辽宁沈阳110035

出　　处：《中国药物滥用防治杂志》2022年第12期1717-1723,共7页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：辽宁省自然科学基金项目(编号:2021-MS-144、2020JH2/10300108);辽宁省教育厅科学研究经费项目(编号:2020191)。

摘　　要：体外代谢技术是借助体外模型模拟研究药物体内代谢和转化途径基础上,确定代谢物,阐明药物作用机理的技术。与体内代谢方法相比,该技术排除了生物体内干扰因素和个体差异的影响,具有成本低、操作简单、重复性好等特点。本文在简要介绍体外代谢研究技术方法的基础上,着重对其在法庭科学毒品物证检验中的应用研究进行综述,以期为涉毒案件物证鉴定提供新的技术方法,进而为案件侦破和诉讼提供科学依据与证据支持。As a technology in studying the metabolic and transformation pathway of drug in vivo and clarifying the mechanism of drug action, in vitro metabolism simulates the metabolic process of drugs in vivo through in vitro model,determines metabolites, eliminates in vivo interference factors and individual differences. The applications of the approach have shown the advantages including low cost, simple operation and good repeatability. Based on a brief introduction of the basic methods of in vitro metabolism, the application of this technology in illicit drugs identification were previewed here,aiming to provide a new technical method for the identification of drug-related case evidence and provide scientific basis and evidence support for case detection and litigation.

关 键 词：法庭科学 体外代谢 毒品 进展 

分 类 号：D918.9[政治法律—法学]