儿童复发性A族链球菌性扁桃体炎免疫机制的研究进展  

Advances in immune mechanism of recurrent group A Streptococcus tonsillitis in children

作　　者：施佳 蔡成[1] SHI Jia;CAI Cheng(Department of Neonatology,Shanghai Children's Hospital,Shanghai Jiaotong University,Shanghai 200062,China)

机构地区：[1]上海交通大学附属儿童医院、上海市儿童医院新生儿科,上海200062

出　　处：《基础医学与临床》2023年第2期336-340,共5页Basic and Clinical Medicine

摘　　要：A族β溶血性链球菌(GAS)是儿童常见感染病原,其引起的扁桃体炎性反应反复发作,即为复发性A族链球菌性扁桃体炎(GAS-RT)。新近研究认为,GAS-RT并非传统意义上的感染性疾病,而是一种免疫敏感性疾病,经由超抗原(SAgs)和生发中心(GC)的滤泡辅助T细胞(Tfh)相互作用,发挥对GC的B细胞细胞毒作用来逃避免疫应答,该理论为临床提供了新的免疫靶向治疗的思路。Group A beta-hemolytic Streptococcus(GAS)is a common infectious agent in children which may cause recurrent inflammation of the tonsils,known as recurrent group A Streptococcus tonsillitis(GAS-RT).Recent studies found that GAS-RT is not an infectious disease as traditional sense,but rather than an immunosensitive disease that evades the immune response through the interaction between superantigens(SAgs)and follicular helper T cells(Tfh)in the germinal center(GC),which exerts a cytotoxic effects on B cells in the GC.This theory suggested a potential new strategy for clinical treatement.

关 键 词：复发性扁桃体炎 免疫机制 链球菌热原外毒素A T滤泡辅助细胞 细菌疗法 

分 类 号：R72[医药卫生—儿科]