过氧化物酶体增殖物激活受体γ辅激活因子-1α对奶牛脂肪肝的调节作用及机制  

Regulatory Effect and Mechanism of Peroxisome Proliferator-Activated Receptor γ Coactivator-1α on Fatty Liver of Dairy Cows

作　　者：安彦昊 马贵 孙奕烁 马燕芬 AN Yanhao;MA Gui;SUN Yishuo;MA Yanfen(Key Laboratory of Ruminant Molecular Cell Breeding in Ningxia,School of Agriculture,Ningxia University,Yinchuan 750021,China;Institute of Animal Nutrition and Feed,Inner Mongolia Academy of Agriculture and Animal Husbandry Sciences,Huhehot 010031,China)

机构地区：[1]宁夏大学农学院,宁夏回族自治区反刍动物分子细胞育种重点实验室,银川750021 [2]内蒙古自治区农牧业科学院,动物营养与饲料研究所,呼和浩特010031

出　　处：《动物营养学报》2023年第1期63-70,共8页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：宁夏自然科学基金项目(2022AAC02006);宁夏大学科研启动项目(030900002154);内蒙古自治区科技计划项目(2021GG0025);内蒙古农牧业创新基金项目(2019CXJJM06);宁夏回族自治区乡村振兴科技成果引进示范推广项目(2021CGSF0206)。

摘　　要：随着畜牧业发展对畜禽养殖和畜产品品质要求的提高,营养代谢疾病在动物群体中的发病率也呈逐渐增加趋势。脂肪肝作为营养代谢性疾病的一种,常发生在围产期高产奶牛群体中,长期处于能量负平衡状态的高产奶牛,过量的动员体脂造成肝脏甘油三酯堆积,从而形成脂肪肝。患有脂肪肝的奶牛不仅会导致其产奶量降低,产犊间隔延长,还会诱发其他疾病的发生,对奶牛的生产性能和畜牧业的发展产生巨大的负面作用。核转录辅激活因子过氧化物酶体增殖物激活受体γ辅激活因子-1α(PGC-1α)参与多种核受体及转录因子相互作用,从而调控相关靶基因的表达。PGC-1α与奶牛脂肪肝、酮病和乳腺炎等疾病有着密切的关系,有可能成为新的疾病治疗靶点。本文综述了PGC-1α调控的各种分子途径,将调控脂质代谢、线粒体功能障碍、氧化应激、胰岛素抵抗和炎症反应联系起来,进一步阐明PGC-1α在奶牛脂肪肝中发挥调节作用的最新研究进展。The incidence of nutritional metabolic diseases in animal population is gradually increasing,with the development of animal husbandry to improve the quality of livestock breeding and livestock products. Fatty liver is a kind of nutritional metabolic disease with a high incidence in perinatal high-yielding dairy cows. During the perinatal period,dairy cows are usually in a negative energy balance,leading to excessive mobilization of body fat,resulting in accumulation of liver triglycerides and thus fatty liver. Dairy cows with fatty liver can reduce milk yield,prolong calving interval,and induce the occurrence of other diseases,which have a huge impact on the production performance of dairy cows and the development of animal husbandry. Peroxisome proliferator-activated receptorγcoactivator-1α(PCC-1α)is an important nuclear transcription coactivator,which participates in the interaction of various nuclear receptors and transcription factors to regulate the expression of related target genes. PCC-1αis closely related to fatty liver,ketosis and mastitis in dairy cows,and may be a new therapeutic target for these diseases. In this review,we reviewed the various molecular pathways involved in the regulation of PGC-1α,and further elucidated the latest research progress on the regulatory role of PGC-1αin fatty liver of dairy cows by regulating lipid metabolism,mitochondrial dysfunction,oxidative stress,insulin resistance and inflammatory response.[Chinese Journal of Animal Nutrition,2023,35(1):63-70]

关 键 词：奶牛 过氧化物酶体增殖物激活受体γ辅激活因子-1α 脂肪肝 作用机制 

分 类 号：S858.23[农业科学—临床兽医学]