中药有效成分对动物疫苗的免疫佐剂效果及相关机理研究进展  

Research Progress on Immune Adjuvant Effect and Related Mechanism of Active Ingredients of Traditional Chinese Medicine on Animal Vaccines

作　　者：刘宏莹 王婧瑜[3] 崔珍珍 马青霞 汪婷婷 李健明[1,4] 时坤 宫庆龙[2] 杜锐 冷雪[1,4] LIU Hongying;WANG Jingyu;CUI Zhenzhen;MA Qingxia;WANG Tingting;LI Jianming;SHI Kun;GONG Qinglong;DU Rui;LENG Xue(College of Chinese Medicine Materials,Jilin Agricultural University,Changchun 130118,China;College of Animal Science and Technology,Jilin Agricultural University,Changchun 130118,China;Jilin Academy of Agricultural Sciences,Changchun 130118;Jilin Provincial Engineering Research Center for Efficient Breeding and Product Development of Sika Deer,Changchun 130118,China)

机构地区：[1]吉林农业大学中药材学院,长春130118 [2]吉林农业大学动物科学技术学院,长春130118 [3]吉林省农业科学院,长春130118 [4]吉林省梅花鹿高效养殖和产品开发技术工程研究中心,长春130118

出　　处：《中国畜牧兽医》2023年第1期390-397,共8页China Animal Husbandry & Veterinary Medicine

基　　金：吉林省科技发展计划技术攻关项目(20190304004YY);阿勒泰地区中药材产业发展规划及规范化种植、评价、产业示范体系建设与推广(0207-202020043)。

摘　　要：佐剂作为疫苗的重要组成部分,其自身的安全性及对疫苗的免疫增强效果受到广泛重视。动物疫苗佐剂种类较多,包括铝佐剂、油乳佐剂和脂质体佐剂等。但由于可应用的佐剂有限,疫苗的需求量增大,因此寻求更加安全有效的疫苗佐剂成为新的研究热潮。中药具有易获取、毒性低和免疫活性强等特点,有潜力成为新型疫苗佐剂。笔者对中药有效成分的佐剂活性、联合疫苗后的免疫调节效果及作用机制进行综述,阐明中药有效成分作为动物疫苗佐剂的可能性及研究进展,为新型佐剂的研制提供理论依据。As an important part of vaccines, adjuvants have received extensive attention for their safety and their immune-enhancing effects on vaccines.There are many kinds of adjuvants for animal vaccines, including aluminum adjuvant, oil emulsion adjuvant and liposome adjuvant.Due to the limited adjuvants available and the increasing demand for vaccines, the search for safer and more effective vaccine adjuvants has become a new upsurge.Traditional Chinese medicine has the characteristics of easy access, low toxicity and strong immune activity.It has the potential to become a new vaccine adjuvant.This article reviewed the adjuvant activity of the active ingredients of traditional Chinese medicine, the immune regulatory effect and the mechanism of action after the combined vaccine, expounded on the possibility and research progress of the active ingredients of traditional Chinese medicine as adjuvants for animal vaccines, and provided a theoretical basis for the development of new adjuvants.

关 键 词：中药 动物疫苗 佐剂 作用机理 

分 类 号：S853.7[农业科学—临床兽医学]