虎黄烧伤搽剂联合头孢类抗菌药物治疗急性创伤临床观察  

Clinical Observation of Huhuang Burn Liniment Combined with Cephalosporins in the Treatment of Acute Traumatic Injury

作　　者：王勇 张华[2] 谭兵 沙前坤 WANG Yong;ZHANG Hua;TAN Bing;SHA Qiankun(Chinese Medicine Hospital of Qijiang District,Chongqing,China 401420;Fuling Hospital Affiliated to Chongqing University,Chongqing,China 408099;Fengdu People's Hospital,Chongqing,China 408299;Chongqing Yangdu Biology Institute,Chongqing,China 400015)

机构地区：[1]重庆市綦江区中医院,重庆401420 [2]重庆大学附属涪陵医院,重庆408099 [3]重庆市丰都县人民医院,重庆408299 [4]重庆央都生物研究院,重庆400015

出　　处：《中国药业》2023年第3期102-105,共4页China Pharmaceuticals

基　　金：重庆市自然科学基金面上项目[cstc2021jcyj-msxmX0367]。

摘　　要：目的探讨虎黄烧伤搽剂联合头孢类抗菌药物对急性创伤患者创面修复及炎性因子水平的影响。方法选取重庆市綦江区中医院2019年7月至2020年8月收治的急性创伤患者278例,按随机摸球法分为观察组和对照组,各139例。两组患者均予头孢类抗菌药物治疗,观察组患者加用虎黄烧伤搽剂治疗,均用药至伤口愈合。结果观察组患者的症状(湿性渗液、瘙痒疼痛、红肿)消失时间和创面愈合时间均显著短于对照组(P<0.05);与治疗前比较,两组患者治疗后的炎性因子(白细胞介素6、C反应蛋白、肿瘤坏死因子-α、降钙素原)水平均显著降低(P<0.05),且观察组均显著低于对照组(P<0.05);观察组患者的血管分布、柔软度、色泽、厚度评分均显著低于对照组(P<0.05)。结论虎黄烧伤搽剂联合头孢类抗菌药物治疗急性创伤的效果较好,能缩短患者的症状消失时间和创面愈合时间,降低炎性因子水平,促进创面修复。Objective To investigate the effect of Huhuang Burn Liniment combined with cephalosporins on the wound surface repair and inflammatory factor levels in patients with acute traumatic injury.Methods A total of 278 patients with acute traumatic injury admitted to the Chinese Medicine Hospital of Qijiang District in Chongqing from July 2019 to August 2020 were selected and divided into the observation group and the control group by the random ball touching method,with 139 cases in each group.The patients in the two groups were treated with cephalosporins,on this basis,the patients in the observation group were treated with Huhuang Burn Liniment.Both groups were treated until the wound was healing.Results The disappearance time of symptoms(wet exudation,pruritus,pain,redness and swelling)and healing time of wound surface in the observation group was significantly shorter than that in the control group(P<0.05).Compared with those before treatment,the levels of inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and procalcitonin(PCT)]in the two groups after treatment were significantly lower(P<0.05),and those in the observation group were significantly lower than those in the control group(P<0.05).The scores of vascular distribution,softness,color and thickness in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Huhuang Burn Liniment combined with cephalosporins is effective in the treatment of acute traumatic injury,which can shorten the time of symptom disappearance and wound surface healing,reduce the level of inflammatory factors,and promote the wound surface healing.

关 键 词：虎黄烧伤搽剂 头孢类抗菌药物 急性创伤 炎性因子 创面修复 

分 类 号：R932[医药卫生—生药学] R285.6[医药卫生—药学]