维生素D改善胰岛素抵抗的研究进展  

Research Progress of Vitamin D in Improving Insulin Resistance

作　　者：邹静雯 王宇茹 王云[1,2] 柏金秀 ZOU Jingwen;WANG Yuru;WANG Yun;BAI Jinxiu(Affiliated Hospital of Hebei University,Baoding,Hebei,China 071000;School of Clinical Medicine,Hebei University,Baoding,Hebei,China 071000)

机构地区：[1]河北大学附属医院,河北保定071000 [2]河北大学临床医学院,河北保定071000

出　　处：《中国药业》2023年第3期127-128,I0001-I0004,共6页China Pharmaceuticals

摘　　要：目的总结维生素D改善胰岛素抵抗的分子机制。方法采用文献分析法,检索PubMed和CNKI数据库中自建库起至2022年3月有关维生素D改善胰岛素抵抗的文献,总结相关分子机制及对胰岛素抵抗的防治现状。结果维生素D可通过氧化还原状态、炎性反应、胰岛素信号转导、细胞内钙离子平衡、免疫应答、表观遗传等分子机制改善胰岛素抵抗,成为防治胰岛素抵抗介导的2型糖尿病(T2DM)等相关疾病的有效途径,目前能有效改善胰岛素抵抗的维生素D治疗浓度为50 ng/mL。结论维生素D能有效改善胰岛素抵抗的基础是受试者的维生素D基线水平较低,维生素D充足的受试者可能对维生素D补充剂相对不敏感,致改善胰岛素抵抗的效果不明显,具体原因尚需深入研究。Objective To summarize the molecular mechanism of vitamin D in improving the insulin resistance.Methods The documents related to the vitamin D in improving insulin resistance in the PubMed and CNKI databases from the inception to March 2022 were searched by the documentary analysis method to summarize the relevant molecular mechanisms and the prevention and treatment of insulin resistance.Results Vitamin D could improve insulin resistance through the redox status,inflammatory response,insulin signal transduction,intracellular calcium balance,immune response,epigenetic regulation and other molecular mechanisms,which become effective ways to prevent and treat insulin resistance-mediated diabetes mellitus type 2(T2DM)and other related diseases.At present,the concentration of vitamin D that could effectively improve the insulin resistance was 50 ng/mL.Conclusion The basis that vitamin D can effectively improving the insulin resistance is the low baseline level of vitamin D in subjects,and the subjects with sufficient vitamin D may be relatively insensitive to vitamin D supplements,which leads to the insignificant effect of improving the insulin resistance,and the specific reasons need to be further studied.

关 键 词：维生素D 胰岛素抵抗 2型糖尿病 分子机制 

分 类 号：R969.4[医药卫生—药理学] R977.24[医药卫生—药学]