Clinical Effects of Bushen Culuan Prescription on Infertility Due to Decreased Ovarian Reserve of Kidney Deficiency and Liver Depression Pattern  

补肾促卵方治疗肾虚肝郁型卵巢功能低下不孕症

作　　者：Yanqi Feng Sujuan Ma 冯艳奇;马素娟(河南医学高等专科学校妇产科教研室,河南郑州;河南中医药大学第一附属医院妇产科,河南郑州)

机构地区：[1]Teaching and Research Department of Gynecology and Obstetrics,Henan Medical College,Zhengzhou,Henan,China [2]Department of Obstetrics and Gynecology,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou,Henan,China

出　　处：《Chinese Medicine and Natural Products》2022年第3期152-157,共6页中医学报（英文）

摘　　要：Objective The objective of this study was to explore the clinical effects of Bushen Culuan prescription on infertility due to decreased ovarian reserve of kidney deficiency and liver depression pattern.Methods Totally 100 infertile patients with ovarian hypofunction treated from October 2019 to January 2022 were selected and divided into the observation group and the control group by a random number table.The control group was treated with estrogen sequential therapy,and the observation group was treated with Bushen Culuan prescription.The clinical efficacy,sex hormone levels including(follicle-stimulating hormone[FSH],luteinizing hormone[LH],and estradiol[E_(2)]),ovarian function,ovarian blood flow status(peak systolic velocity[PSV],antral follicle count[AFC],arterial pulse index[PI],and resistance index[RI]),and pregnancy outcome in the two groups were compared and analyzed.Results The total effective rate of the observation group(96.00%)was significantly higher than that of the control group(80.00%).The difference was statistically significant(p<0.05).Before treatment,there was no significant difference in sex hormone levels(FSH,LH,E_(2),and FSH/LH),ovarian function(number of primary follicles,number of dominant follicles,ovulation number,and endometrial thickness),and ovarian blood flow(PSV,RI,PI,and AFC)between the two groups(p>0.05).After treatment,the levels of serum hormones FSH,LH,E_(2),and FSH/LH decreased significantly in both groups.The number of primary follicles,dominant follicles,and ovulation increased significantly,and the thickness of endometrium decreased significantly;the indexes of PSV,RI,and AFC of ovarian blood flow increased significantly,and the PI index decreased significantly.The levels of each index in the observation group were better than those in the control group(p<0.05).In the control group,32 cases were pregnant within 1 year after treatment,and the pregnancy rate was 64.00%;21 cases in the observation group were pregnant within 1 year after treatment,and the pregnancy rate was 4目的:探索补肾促卵方治疗肾虚肝郁型卵巢功能低下不孕症的临床疗效。方法:选择在2019年10月至2022年1月收治的卵巢功能低下不孕症患者100例为研究对象,采用随机数字表法平均分为观察组、对照组。对照组采用雌激素序贯疗法,观察组采用补肾促卵方治疗,对比分析两组患者在治疗后临床疗效、性激素水平[卵泡刺激素(follicle stimulate hormone,FSH)、促黄体生成素(Luteinizing Hormone,LH)、雌二醇(Estradiol,E2)]、卵巢功能、卵巢血流状态[收缩期峰值流速(PSV)、窦卵泡计数(AFC)、动脉搏动指数(PI)、阻力指数(RI)]及妊娠结局等指标。结果:观察组有效率(96.00%)明显高于对照组(80.00%),差异具有统计学意义(P<0.05)。治疗前,两组患者性激素水平(FSH、LH、E2、FSH/LH)、卵巢功能(初级卵泡数量、优势卵泡数、排卵数、子宫内膜厚度)、卵巢血流(PSV、RI、PI、AFC)相比,差异无统计学意义(P>0.05)。治疗后,两组患者血清激素FSH、LH、E2、FSH/LH水平均明显下降;初级卵泡数量、优势卵泡数、排卵数均明显升高,子宫内膜厚度显著降低;卵巢血流PSV、RI、AFC指标明显升高,PI指标显著降低,且观察组各指标水平优于对照组,差异具有统计学意义(P<0.05)。观察组患者在治疗后1年内妊娠32例,妊娠率为64.00%;对照组患者在治疗后1年内妊娠21例,妊娠率为42.00%;观察组妊娠率高于对照组,组间比较差异具有统计学意义(〖STBX〗χ2〖STBZ〗=4.014,P=0.045<005)。结论:补肾促卵方对卵巢功能低下不孕症疗效确切,其作用机制可能是通过多成分、多靶点的刺激作用,发挥改善患者卵巢功能,调节性激素水平等作用,进而提高妊娠结局。

关 键 词：INFERTILITY Bushen Culuan prescription ovarian hypofunction estrogen sequential therapy 

分 类 号：R271.14[医药卫生—中医妇科学]