血浆乙醛脱氢酶2在慢性心功能不全合并多脏器功能损害患者中的表达及临床意义  

Expression and Clinical Significance of Plasma Aldehyde Dehydrogenase 2 in Patients with Chronic Heart Failure Complicated by Multiple Organ Dysfunction

作　　者：王乾辉 王真[1] 沈剑 WANG Qianhui;WANG Zhen;SHEN Jian(Department of Respiratory and Critical Care Medicine,the Third People’s Hospital of Chengdu(Chengdu Respiratory Health Research Institute),Chengdu City,Sichuan Province 610031)

机构地区：[1]四川省成都市第三人民医院(成都市呼吸健康研究所)呼吸与危重症医学科,610031

出　　处：《医学理论与实践》2023年第3期365-368,376,共5页The Journal of Medical Theory and Practice

摘　　要：目的:探究血浆乙醛脱氢酶2(ALDH2)在慢性心功能不全(CHF)合并多脏器功能损害(MOD)患者中的表达及临床意义。方法:选取本院诊治的CHF患者91例,按是否合并MOD分为CHF组(51例)、CHF合并MOD组(40例);另选取MOD患者46例作为MOD组,体检健康者42例为健康组。比较四组血浆ALDH2、脂蛋白a[LP(a)]、高密度脂蛋白胆固醇(HDL-C)水平;Logistic回归分析各指标对CHF合并MOD的影响;Pearson相关分析ALDH2与LP(a)、HDL-C的相关性;采用受试者工作特征曲线(ROC曲线)评估各指标预测CHF患者并发MOD的价值。结果:血浆ALDH2、HDL-C水平在CHF合并MOD组MOD组>CHF组>健康组,差异有统计学意义(P<0.05);多因素Logistic回归分析显示,血浆ALDH2、HDL-C升高是CHF并发MOD的保护性因素(P<0.05),LP(a)升高是危险因素(P<0.05);Pearson相关性分析显示,ALDH2与LP(a)呈显著负相关(r=-0.691,P<0.01),与HDL-C呈显著正相关(r=0.448,P<0.01)。ALDH2预测CHF并发MOD的AUC为0.947,预测准确性高于LP(a)、HDL-C(均AUC=0.796),而三项联合AUC为0.956,预测准确性最高。结论:血浆ALDH2在CHF合并MOD患者中呈相对低表达,与LP(a)、HDL-C显著相关,ALDH2可能与LP(a)、HDL-C共同参与CHF患者并发MOD的过程;且三项指标联合可提高对CHF并发MOD的预测价值。Objective:To investigate the expression and clinical significance of plasma acetaldehyde dehydrogenase 2(ALDH2)in patients with chronic heart failure(CHF)complicated with multiple organ dysfunction(MOD).Methods:91 CHF patients diagnosed and treated in our hospital were divided into CHF group(51 cases)and CHF combined with MOD group(40 cases)according to whether they were combined with MOD;46 cases of MOD patients were selected as MOD group,and 42 cases of healthy people were considered healthy group.The plasma levels of ALDH2,lipoprotein a[LP(a)],and high-density lipoprotein cholesterol(HDL-C)were compared among the four groups;Logistic regression analysis was performed to analyze the effect of each index on CHF combined with MOD;Pearson correlation analysis was performed to analyze the relationship between ALDH2 and LP(a),Correlation of HDL-C;receiver operating characteristic curve(ROC curve)was used to evaluate the value of each index in predicting CHF patients complicated with MOD.Results:Plasma ALDH2 and HDL-C levels were significantly different in CHF combined MOD groupMOD group>CHF group>healthy group(P<0.05);multivariate Logistic regression analysis showed that elevated plasma ALDH2 and HDL-C were protective factors for CHF complicated with MOD(P<0.05),and elevated LP(a)was a risk factor(P<0.05);Pearson correlation Sexual analysis showed that ALDH2 was significantly negatively correlated with LP(a)(r=-0.691,P<0.01),and significantly positively correlated with HDL-C(r=0.448,P<0.01).The AUC of ALDH2 in predicting CHF complicated with MOD was 0.947,and the prediction accuracy was higher than that of LP(a)and HDL-C(both AUC=0.796),while the combined AUC of the three items was 0.956,and the prediction accuracy was the highest.Conclusion:Plasma ALDH2 is relatively low expressed in CHF patients complicated with MOD,and is significantly correlated with LP(a)and HDL-C.ALDH2 may be involved in the process of CHF patients complicated with MOD together with LP(a)and HDL-C.Federation increases the predictive value of C

关 键 词：乙醛脱氢酶2 慢性心功能不全 多脏器功能损害 脂蛋白A HDL-C 

分 类 号：R541.6[医药卫生—心血管疾病]