Bronchial inflammatory profile in interferon-gamma-mediated immune response in asthma patients during airway response to cold stimulus  

作　　者：Juliy M.Perelman Aleksey B.Pirogov Anna G.Prikhodko Victor P.Kolosov 

机构地区：[1]Far Eastern Scientific Center of Physiology and Pathology of Respiration,22 Kalinina Str.,Blagoveshchensk 675000,Russia

出　　处：《Frigid Zone Medicine》2022年第4期244-250,共7页寒地医学（英文）

摘　　要：Objective:To evaluate the inflammatory pattern and the interferon(IFN)-γin the bronchial secretion of asthma patients in response to acute cold bronchoprovocation.Material and methods:We enrolled 42 patients with asthma.We assessed asthma by Asthma Control Test,the lung function by spirometry before and after the bronchodilator test,followed by collecting induced sputum.The next day,we collected exhaled breath condensate(EBC)and conducted a 3-minute isocapnic hyperventilation with cold air(IHCA),followed by collecting spontaneously produced sputum.Results:Group 1 included 20 patients with cold airway hyperresponsiveness(CAHR),and group 2 included 22 patients without CAHR.In both groups,a high level of neutrophils in bronchial secretion was observed before and after IHCA.In response to IHCA,the number of epitheliocytes in the sputum decreased to a greater extent in patients of group 1.The baseline epitheliocytes and the concentration of IFN-γafter IHCA had an inverse relationship(r=-0.60;P=0.017).The baseline IFN-γin EBC before and after IHCA was lower in group 1.Airway response to cold exposure directly correlated with IFN-γlevels after IHCA(Rs=0.42;P=0.014).Conclusion:In asthma patients with CAHR,there is a relationship between the persistence of mixed inflammation and the level of IFN-γin the bronchi.IFN-γin response to IHCA is decreased with increased cytokine utilization during cold bronchospasm,which is accompanied by the mobilization of neutrophils and the shift in the cytokine spectrum of the respiratory tract towards the T helper cells(Th)1 immune response.

关 键 词：ASTHMA cold airway hyperresponsiveness mixed pattern of bronchial inflammation pro-inflammatory interferon-γ T helper cells 1 immune response 

分 类 号：R562.21[医药卫生—呼吸系统]