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作 者:Fefelova Elena Viktorovna Karavaeva Tatyana Mikhailovna Parshina Anastasia Anatolyevna Ma Van De Vasilina Denisovna Tereshkov Pavel Petrovich
机构地区:[1]Department of Pathological Physiology,Chita State Medical Academy,Chita 672090,Russia [2]Department of Chemistry and Biochemistry,Chita State Medical Academy,Chita 672090,Russia [3]Department of Faculty Therapy,Chita State Medical Academy,Chita 672090,Russia [4]Laboratory of Experimental and Clinical Biochemistry and Immunology,Chita State Medical Academy,Chita 672090,Russia
出 处:《Frigid Zone Medicine》2023年第1期37-41,共5页寒地医学(英文)
基 金:This study was approved by the Medical Ethics Commission of Chita State Medical Academy(No.104,2020-11-11);informed consent in writing was provided by the legal guardians.
摘 要:Objective:Clinical manifestation of the inflammatory process in its relation to biochemical markers(total cysteine[Cys],cysteine-glycine[CysGly],glutathione[GSH],glutamate-cysteine[Glu-Cys],homocysteine[Hcy],the ratio of reduced to oxidized glutathione[GSH/GSSG],the ratio of reduced to oxidized cysteine[CySH/CySS],malondialdehyde-oxidized low-density lipoproteins[MDA-oxLDL])has been studied in patients with coronavirus disease 2019(COVID-19).Material and methods:48 patients with mild to severe COVID-19 and 20 healthy volunteers were included in our research.The participants were divided into 4 experimental groups according to inflammation intensity estimated based on the serum levels of interleukin 6(IL-6).Results:All 4 groups showed the prevalence of male patients and elevated serum levels of IL-6(by 54.6%).There was no comorbidity in patients with mild COVID-19(nasopharyngitis symptoms)and in healthy control subjects.50%of patients with lung damage had accompanying diseases.Alterations of aminoethyl metabolism were detected in COVID-19 patients:as reflected by the decreased levels of Cys,CysGly,and Glu-Cys and the increased levels of GSH as compared to the control group.Conclusion:Elevation of IL-6 over 7.5 pg/mL was associated with decreased GSH/GSSG and CySH/CySS ratios indicating enhanced oxidative stress and was followed by protein oxidation,specifically MDA-oxLDL.
关 键 词:coronavirus disease 2019 AMINOTHIOLS oxidative stress INTERLEUKIN-6 oxidized lipoproteins
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