幽门螺旋杆菌抗体、胃蛋白酶原、促胃液素-17与胃癌临床分期的相关性  

Correlation between helicobacter pylori antibody,pepsinogen and gastrin-17 and clinical staging of gastric cancer

作　　者：张振山[1] 姚天宇[2] 许迪[3] ZHANG Zhenshan;YAO Tianyu;XU Di(Department of Radiotherapy and Chemotherapy,Cangzhou Integrated Traditional Chinese and Western Medicine Hospital of Hebei province,Cangzhou 061001,China;Department of Internal Medicine-Cardiovascular,Cangzhou Integrated Traditional Chinese and Western Medicine Hospital of Hebei province,Cangzhou 061001,China;Department of Spleen,Stomach and Hepatology,Cangzhou Integrated Traditional Chinese and Western Medicine Hospital of Hebei Province,Cangzhou 061001,China)

机构地区：[1]河北省沧州中西医结合医院放化疗科,河北沧州061001 [2]河北省沧州中西医结合医院心内科,河北沧州061001 [3]河北省沧州中西医结合医院脾胃肝病科,河北沧州061001

出　　处：《医学研究与教育》2022年第6期29-34,共6页Medical Research and Education

基　　金：河北省医学科学研究重点课题计划项目(162302180)。

摘　　要：目的分析幽门螺旋杆菌抗体、胃蛋白酶原、促胃液素-17与胃癌临床分期的相关性。方法回顾性分析2015年4月至2017年4月收治的120例胃癌患者临床资料,并以70例胃炎患者做对照,比较不同临床分期胃癌患者血清幽门螺旋杆菌抗体阳性率、胃蛋白酶原水平、促胃液素-17,Spearman相关性分析上述因子与胃癌的相关性。结果胃癌患者幽门螺旋杆菌抗体阳性比例高于对照组(P<0.05),Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期患者幽门螺旋杆菌抗体阳性比例逐渐升高;胃癌患者血清中胃蛋白酶原Ⅱ及促胃液素-17高于对照组(P<0.05),胃蛋白酶原Ⅰ低于对照组(P<0.05);Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期患者血清胃蛋白酶原Ⅱ及促胃液素-17逐渐升高,胃蛋白酶原Ⅰ水平逐渐降低;在多元线性回归分析中,幽门螺旋杆菌抗体、胃蛋白酶原Ⅱ和促胃液素-17的回归系数分别为0.396、0.059和0.047,而胃蛋白酶原Ⅰ的回归系数为-0.040。结论幽门螺旋杆菌抗体、胃蛋白酶原、促胃液素-17与胃癌的临床分期相关。Objective To analyze the correlation between helicobacter pylori antibody,pepsinogen,gastrin-17 and the clinical stage of gastric cancer.Methods The clinical data of 120 patients with gastric cancer treated in our hospital from April 2015 to April 2017 were retrospectively analyzed.70 gastritis patients were used as controls to compare the positive rate of serum helicobacter pylori antibody,pepsinogen level and gastrin-17 level in patients with gastric cancer at different clinical stages.Spearman correlation was used to analyze the correlation between the above factors and gastric cancer.Results The positive rate of helicobacter pylori antibody in patients with gastric cancer was higher than that in the control group(P<0.05),and the positive rate of helicobacter pylori antibody in patients with stageⅠ,Ⅱ,ⅢandⅣincreased gradually.The levels of serum pepsinogenⅡ,gastrin-17 in patients with gastric cancer were higher than those in the control group,and the levels of pepsinogenⅠwere lower than those in the control group(P<0.05).The levels of serum pepsinogenⅡand gastrin-17 in patients with stageⅠ,Ⅱ,ⅢandⅣincreased gradually,and the levels of pepsinogen I decreased gradually.In the multiple linear regression analysis with clinical stage of gastric cancer,the regression coefficients of helicobacter pylori antibody,pepsinogenⅡand gastrin-17 were 0.396,0.059 and 0.047,respectively,the regression coefficient of pepsinogen I was-0.040.Conclusion Helicobacter pylori antibody,pepsinogen and gastrin-17 are closely related to the clinical stage of gastric cancer.

关 键 词：幽门螺旋杆菌抗体 胃蛋白酶原 促胃液素-17 胃癌 

分 类 号：P73[天文地球—海洋科学]