Taming Reactive Oxygen Species:Mitochondria-Targeting Aggregation-Induced Emission Luminogen for Neuron Protection via Photosensitization-Triggered Autophagy  

作　　者：Chao Chen Ruoyao Zhang Jianyu Zhang Yufan Zhang Haoke Zhang Zaiyu Wang Xiaolin Huang Sijie Chen Ryan T.K.Kwok Jacky W.Y.Lam Dan Ding Ben Zhong Tang 

机构地区：[1]Department of Chemistry,Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction,Institute for Advanced Study,State Key Laboratory of Molecular Nanoscience,Division of Life Science,Department of Chemical and Biological Engineering,The Hong Kong University of Science and Technology,Clear Water Bay,Kowloon,Hong Kong 999077 [2]State Key Laboratory ofMedicinal Chemical Biology,Key Laboratory of Bioactive Materials,Ministry of Education,College of Life Sciences,Nankai University,Tianjin 300071 [3]Ming Wai Lau Centre for Reparative Medicine,Karolinska Institutet,Hong Kong 999077 [4]Center for Aggregation-Induced Emission,SCUT-HKUST Joint Research Institute,State Key Laboratory of Luminescent Materials and Devices,South China University of Technology,Guangzhou 510640 [5]Shenzhen Institute of Aggregate Science and Technology,School of Science and Engineering,The Chinese University of Hong Kong,Shenzhen 518172 [6]AIE Institute,Guangzhou Development District,Huangpu,Guangzhou 510530

出　　处：《CCS Chemistry》2022年第7期2249-2257,共9页中国化学会会刊（英文）

基　　金：financially supported by the National Science Foundation of China(nos.21788102,51873092,and 51961160730);the Research Grants Council of Hong Kong(nos.16305518,16305618,N-HKUST609/19,AHKUST605/16,and C6009-17G);the Innovation and Technology Commission(nos.ITC-CNERC14SC01 and ITCPD/17-9);Ming Wai Lau Centre for Reparative Medicine Associate Member Program(no.MWLC19SC02);the National Key Research and Development Program of China(no.2017YFE0132200).

摘　　要：Oxidative damage to cells leads to accumulated harmful wastes,which in turn aggravate the imbalance of reactive oxygen species(ROS)and related diseases.Therefore,provoking the cellular defense system against severe oxidation and maintaining ROS homeostasis are desired.Herein,we designed and synthesized a powerful mitochondria-targeting aggregation-induced emission photosensitizer(named DTCSPY)by maximal restriction of heat dissipation.It is demonstrated that taming ROS generation within mitochondria through photosensitization-triggered autophagy via DTCSPY achieved a better neuroprotective effect against oxidative damages than Nacety-L-cysteine and vitamin C.This work not only provides a new way to design high-performance photosensitizers by regulating the photophysical property,but also verifies the concept that taming ROS can be used for cell protection against destructive oxidation,thereby displaying broad prospects for alleviating oxidation-related diseases and promoting cell-based therapy.

关 键 词：aggregation-induced emission mitochondrial targeting PHOTOSENSITIZER reactive oxygen species neuron protection 

分 类 号：O64[理学—物理化学]