Multidimensional Mass Spectrometry Assisted Metallo-Supramolecular Chemistry  

作　　者：Heng Wang Chenxing Guo Xiaopeng Li 

机构地区：[1]College of Chemistry and Environmental Engineering,Shenzhen University,Shenzhen 518073 [2]Shenzhen University General Hospital,Shenzhen University Clinical Medical Academy,Shenzhen 518055

出　　处：《CCS Chemistry》2022年第3期785-808,共24页中国化学会会刊（英文）

基　　金：X.L.acknowledges the support from the Developmental Fund for Science and Technology of Shenzhen government(grant no.RCJC20200714114556036);Tencent Funders Alumni Foundation.H.W.thanks the support from the National Natural Science Foundation of China(no.22001176).

摘　　要：Metallo-supramolecular chemistry based on the reversible,directional,and predictable noncovalent interaction of metal–ligand coordination has been widely applied in constructing a myriad of two-and threedimensional supramolecules with sophisticated structures.The development of metallo-supramolecular chemistry highly relies on facile characterization methods.For advancement of structural complexity with desired functions,however,conventional crystallographicandspectroscopiccharacterizationsarelimited by crystal growth,sample purity,and severe signal overlaps.With high sensitivity and low requirement for purity,multidimensional mass spectrometry(MS),including electrospray ionization-MS(ESI-MS),tandem MS(MS2),and ion mobility-MS(IM-MS),is emerging as an essential analytical tool for characterization of the chemical compositions,connectivity,stability,shape,and size of metallo-supramolecules,as well as kinetic and thermodynamic features of self-assembly processes.Thus,this review mainly focuses on the recentdevelopment ofmultidimensionalMSinmetallosupramolecular characterization and discusses how ESI-MS,MS2,and IM-MS assist the development of metallo-supramolecular chemistry.

关 键 词：mass spectrometry ion mobility SELFASSEMBLY metallo-supramolecules 

分 类 号：O62[理学—有机化学]