High-Performance Photocathodic Bioanalysis Based on Core-Shell Structured Cu_(2)O@TiO_(2) Nanowire Arrays with Air–Liquid–Solid Joint Interfaces  

作　　者：Zhaohong Wang Liping Chen Dandan Wang Zhenyao Ding Xiqi Zhang Xinjian Feng Lei Jiang 

机构地区：[1]College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou 215123 [2]Key Laboratory of Bio-Inspired Materials and Interfacial Science,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190 [3]School of Future Technology,University of Chinese Academy of Sciences,Beijing 101407

出　　处：《CCS Chemistry》2022年第3期1044-1053,共10页中国化学会会刊（英文）

基　　金：supported by the National Key R&D Program of China(no.2019YFA0709200);National Natural Science Foundation of China(nos.21988102,51772198,and 22002101).

摘　　要：Developing photoelectrochemical(PEC)bioassays based on the principle of a photocathodic measurement of enzymatic product H_(2)O_(2) is highly attractive because it can naturally avoid interfering signals arising from reductive species inherent to biofluids.However,fluctuant oxygen levels in the analyte solution can compromise the accuracy of photocathodic bioanalysis and restrict its application because oxygen reduction potential is similar to H_(2)O_(2).Herein,we addressed this restriction by constructing a triphase biophotocathode with air–liquid–solid joint interfaces by immobilizing an oxidase enzyme film on the tip part of superhydrophobic p-type semiconductor nanowire arrays.Such a triphase biophotocathode has a reaction zone with steady and air phasedependent oxygen concentration which stabilizes and increases the oxidase kinetics,and enables the photocathodic measurement principle in reliable PEC bioassay development with high selectivity,good accuracy,and a wide linear detection range.Moreover,the biophotocathode shows good stability during repeated testing under light illumination.This reliable PEC bioassay system has broad potential in the fields of disease diagnosis,medical research,and environmental monitoring.

关 键 词：SUPERHYDROPHOBICITY triphase interface PHOTOCATHODE PHOTOELECTROCHEMICAL BIOANALYSIS 

分 类 号：O62[理学—有机化学]