Electrochemical Aziridination of Tetrasubstituted Alkenes with Ammonia  

作　　者：Shuai Liu Wenxuan Zhao Jin Li Na Wu Chang Liu Xin Wang Shuohao Li Yan Zhu Yong Liang Xu Cheng 

机构地区：[1]Jiangsu Key Laboratory of Advanced Organic Materials,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing,Jiangsu 210023 [2]Jiangsu Provincial Engineering Laboratory of Advanced Materials for Salt Chemical Industry,College of Chemical Engineering,Huaiyin Institute of Technology,Huaian,Jiangsu 223003 [3]Henan-Macquarie University Joint Center for Biomedical Innovation,School of Life Sciences,Henan University,Kaifeng,Henan 475004 [4]State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071

出　　处：《CCS Chemistry》2022年第2期693-703,共11页中国化学会会刊（英文）

基　　金：supported by the National Natural Science Foundation of China(nos.22071105,22031008,21803030,and 22001089);QingLan Project of Jiangsu Education Department,and the Jiangsu Innovation&Entrepreneurship Talents Plan in China.J.L.appreciates the support from the Nature Science Foundation of Jiangsu Province(no.BK20191046).

摘　　要：Ammonia(NH3)is an ideal nitrogen source in terms of availability,reactivity,safety,atom economy,environmental compatibility,and ease of isolation.However,its utility for amine synthesis is limited by its high bond dissociation energy,its strong coordination ability,and the difference between its reactivity and that of the product amines.Herein,we reported the first electrochemical protocol for direct syntheses of unprotected tetrasubstituted aziridines with NH3 and alkenes in the absence of an oxidant,which are highly challenging to achieve by other methods.The combination of graphite felt as the anode material and MeOH as the solvent was the key to the success of the protocol,and the effects of these factors were investigated by means of cyclic voltammetry and density functional theory calculations.

关 键 词：AMMONIA AZIRIDINATION ELECTROCHEMICAL graphite felt AMINATION 

分 类 号：O62[理学—有机化学]