Monte Carlo simulation based thinning and calculating method for noninvasive blood glucose sensing by near-infrared spectroscopy  

作　　者：Congcong Ma Jia Qin Qi Zhang Junsheng Lu Kexin Xu Jingying Jiang 

机构地区：[1]Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments College of Precision Instruments B Opto-electronics Engineering Tianjin University(TU),92#Weijin Road Nankai District,Tianjin 300072,P.R.China [2]San Francisco,Ophthalmology,University of Caliorrnia 480 North Civic Drive 106 Walnut Creek,California 94596,United States [3]State Key Laboratory of Precision Measuring Technology and Instruments College of Precision Instruments Opto-electronics Engineering Tianjin University(TU)92#Weijin Road,Nankai District Tianjin 300072,P.R.China

出　　处：《Journal of Innovative Optical Health Sciences》2017年第2期40-51,共12页创新光学健康科学杂志（英文）

基　　金：the National High Technology Research and Development Program of China(863 Program:2012AA022602);the 111 Project(B07014)and Tianjin Natural Science Foundation(No.16JCZDJC31200).

摘　　要：Previous results show that the floating reference theory(FRT)is an effective tool to reduce the infuence of interference factors on noninvasive blood glucose sensing by near infrared spectros-copy(NIRS).It is the key to measure the floating reference point(FRP)precisely for the application of FRT.Monte Carlo(MC)simulation has been introduced to quantitatively in-vestigate the effects of positioning errors and light source drifts on measuring FRP.In this article,thinning and calculating method(TCM)is proposed to quantify the positioning error.Mean-while,the normalization process(NP)is developed to significantly reduce the error induced by light source drift.The results according to TCM show that 7 purm deviations in positioning can generate about 10.63%relative error in FRP.It is more noticeable that 1%fluctuation in light source intensity may lead to 12.21%relative errors.Gratifyingly,the proposed NP model can effectively reduce the error caused by light source drift.Therefore,the measurement system for FRPs must meet that the positioning error is less than 7 purm,and the light source drift is kept within 1%.Furthermore,an improvement for measurement system is proposed in order to take advantage of the NP model.

关 键 词：Thinning and calculating method Monte Carlo simulation noninvasive blood glucose sensing foating reference theory positioning error light source drift. 

分 类 号：TN9[电子电信—信息与通信工程]