原发性纤维肌痛综合征患者外周血细胞因子水平的Meta分析  

Meta-analysis of peripheral blood cytokine levels in patients with primary fibromyalgia syndrome

作　　者：刘雅妮[1] 牛红青[2] LIU Yani;NIU Hongqing(Department of General Medicine,Affiliated Hospital of Guilin Medical University,Guilin 541001,Guangxi,China;Department of Rheumatology and Immunology,the Second Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi,China)

机构地区：[1]桂林医学院附属医院全科医疗科,广西桂林541001 [2]山西医科大学第二医院风湿免疫科,山西太原030001

出　　处：《右江医学》2023年第1期75-82,共8页Chinese Youjiang Medical Journal

基　　金：广西壮族自治区中医药管理局自筹经费科研课题(GZZC2019142);广西壮族自治区卫生健康委员会自筹经费科研课题(Z20190719);桂林医学院教学研究与改革项目(JG202030);桂林医学院全科医学院教育教学研究与改革项目(GYQKYB214)。

摘　　要：目的采用Meta分析方法评估原发性纤维肌痛综合征(fibromyalgia syndrome,FMS)患者外周血几种常见炎性细胞因子(IL-1β、IL-6、IL-8、TNF-α、IL-10)的水平,从而明确这些炎性细胞因子是否参与原发性FMS的发病过程,探讨原发性FMS的可能发病机制。方法计算机全面检索EMBase、PubMed、中国生物医学文献数据库(CBMdisc)、中国知网(CNKI)、万方数据库、维普等电子数据库,收集原发性FMS患者外周血细胞因子的相关临床研究,检索时间均为建库至2021年9月。2名研究者独立提取纳入文献数据并进行文献质量评价,进一步以标准化均数差(SMD)及其95%CI为合并效应量,应用Stata 12.0软件进行Meta分析。结果最终纳入20篇文献、1658例参与者(953例原发性FMS患者和705例健康对照)。Meta分析结果显示,原发性FMS患者外周血IL-6、IL-8细胞因子水平与健康对照组比较差异均有统计学意义(SMD=0.81,95%CI:0.29~1.33,P<0.05;SMD=0.71,95%CI:0.24~1.18,P<0.05)。原发性FMS患者外周血IL-1β、TNF-α、IL-10细胞因子水平与健康对照组比较差异均无统计学意义(SMD=-0.18,95%CI:-0.82~0.46,P>0.05;SMD=0.08,95%CI:-0.52~0.67,P>0.05;SMD=-0.45,95%CI:-2.06~1.15,P>0.05)。结论当前证据显示,原发性FMS患者外周血IL-6、IL-8水平高于健康对照组。受纳入研究数量和质量的限制,上述结论有待更多更高质量研究予以验证。Objective To evaluate,through meta-analysis,the levels of some common inflammatory cytokines(IL-1β,IL-6,IL-8,TNF-α,IL-10)in peripheral blood of patients with primary fibromyalgia syndrome(FMS),and to further determine whether these inflammatory cytokines were involved in the pathogenesis of primary FMS and explore the potential pathogenic mechanism of primary FMS.Methods Clinical studies related to peripheral blood cytokines in patients with primary FMS were searched out from databases like EMBase,PubMed,China Biology Medicine disc(CBMdisc),CNKI,Wanfang,and VIP,etc.The retrieval time was from the establishment of the database to September 2021.Data extraction and quality evaluation were independently completed by two researchers.The standardized mean difference(SMD)and its 95%CI were used as the combined effect size,and Stata 12.0 was employed for meta-analysis.Results 20 articles and 1658 participants(953 patients with primary FMS in study group and 705 healthy cases in healthy control group)were included in this study.Meta analysis showed that differences in the levels of serum IL-6 and IL-8 between the study group and the healthy control group were all statistically significant(SMD=0.81,95%CI:0.29–1.33,P<0.05;SMD=0.71,95%CI:0.24–1.18,P<0.05).There were no statistically significant differences in the levels of serum IL-1β,TNF-αand IL-10 between the two groups(SMD=-0.18,95%CI:-0.82–0.46,P>0.05;SMD=0.08,95%CI:-0.52–0.67,P>0.05;SMD=-0.45,95%CI:-2.06–1.15,P>0.05).Conclusion Current evidence shows that the levels of IL-6 and IL-8 in the peripheral blood of patients with primary FMS are higher than those in the healthy control group,which needs to be further verified with more and higher quality studies due to the limitations of quantity and quality in this study.

关 键 词：纤维肌痛综合征 细胞因子 IL-1β IL-6 IL-8 TNF-α IL-10 META分析 

分 类 号：R685[医药卫生—骨科学]