中西医结合治疗浆细胞性乳腺炎肿块期肝郁胃热证的临床效果研究  

Clinical observation of integrated traditional Chinese and Western medicine in the treatment of tumor stage plasma cell mastitis with liver stagnation and stomach heat syndrome

作　　者：乔楠 丁晓雯 方勇 倪毓生 陈德轩 马朝群 QIAO Nan;DING Xiao-wen;FANG Yong(Department of General Surgery,Nantong Hospital Affiliated to Nanjing University of Chinese Medicine,Nantong(226001),China)

机构地区：[1]南京中医药大学附属南通医院,南通226001 [2]南京中医药大学附属医院,南京210000

出　　处：《中国中西医结合外科杂志》2023年第1期67-73,共7页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：南通大学校级科研基金临床医学专项青年项目(2019LQ018);南通市卫生健康委员会青年课题(QA2020013)。

摘　　要：目的:观察疏肝散结汤联合蓝丁格尔乳腺治疗仪及抗生素治疗对浆细胞性乳腺炎急性肿块期肝郁胃热证的临床疗效。方法:选取我院2020年1月—2021年8月收治的浆细胞性乳腺炎急性肿块期肝郁胃热证患者共41例,根据随机数字表法将患者分为治疗组21例和对照组20例。对照组予以蓝丁格尔乳腺治疗仪治疗4周,抗生素静脉滴注2周,口服2周;治疗组在对照组基础上予以疏肝散结汤口服4周。观察项目包括症状体征指标(肿块大小、疼痛、肤色、肤温)、实验室指标[白细胞计数(WBC)、C反应蛋白(CRP)、白细胞介素6(IL-6)、红细胞沉降率(ESR)、肝素结合蛋白(HBP)及血清泌乳素(PRL)]、中医疗效判定(中医临床疗效、中医症状和体征积分)及焦虑抑郁评分。结果:治疗组患者症状体征指标、中医临床疗效、中医症状和体征积分及焦虑抑郁评分均明显改善,差异有统计学意义(P<0.05),两组均无不良事件发生。结论:疏肝散结汤联合蓝丁格尔乳腺治疗仪及抗生素治疗能有效改善浆细胞性乳腺炎患者的局部及全身症状,改善中医症状体征,缓解患者的焦虑抑郁情绪,安全且有效。Objective To observe the clinical effect of Shugan Sanjie Decoction combined with Landgale Breast Therapy Apparatus and antibiotics in treating plasma cell mastitis with liver stagnation and stomach heat syndrome in acute mass stage.Methods A total of 41 patients with liver stagnation and stomach heat syndrome in acute mass stage of plasma cell mastitis were selected,and the patients were divided into a treatment group of 21 cases and a control group of 20 cases according to the random number table method.The control group was treated with Landgale Breast Therapy Apparatus for 4 weeks,antibiotics were intravenously infused for 2 weeks,and oral administration was given for 2 weeks;the treatment group was treated with Shugan Sanjie Decoction orally for 4 weeks on the basis of the control group.Observation of symptoms and signs(tumor size,pain,skin color,skin temperature),TCM efficacy judgment(TCM clinical efficacy,TCM symptom and sign score),laboratory indicators(WBC,CRP,IL-6,ESR,HBP,PRL),anxiety and depression scores.Results Symptoms and signs indicators,clinical efficacy judgment of traditional Chinese medicine,scores of symptoms and signs of traditional Chinese medicine,laboratory indicators and anxiety and depression scores in the treatment group were significantly improved(P<0.05).All indexes except WBC were better than those in the control group(P<0.05),and there were no adverse events in the two groups.Conclusion Shugan Sanjie Decoction combined with antibiotics and Landgale Breast Therapy Apparatus can effectively improve the Symptoms and signs of patients with plasma cell mastitis,improve the symptoms and signs of TCM,and relieve anxiety and depression of patients,which is safe and effective.

关 键 词：浆细胞性乳腺炎 疏肝散结汤 中西医结合 焦虑抑郁 

分 类 号：R269[医药卫生—中西医结合]