柠檬酸交联固定化小球藻复合材料的制备及药物缓释性能  

Preparation of Citric Acid Crosslinking Immobilized Chlorella Composite and Drug Slow-Release Performance

作　　者：李豪 白波[1] 裴柯 罗钰[1] 梁琳琳 王贺铭 彭可慧 曹芳利 Hao Li;Bo Bai;Ke Pei;Yu Luo;Linlin Liang;Heming Wang;Kehui Peng;Fangli Cao(Key Laboratory of Subsurface Hydrology and Ecological Effect in Aird Region(Chang’an University),Ministry of Education,Xi’an 710054,China;Design and Research Institute of Shaanxi Construction Installation Group,Xi’an 710054,China)

机构地区：[1]长安大学旱区地下水文与生态效应教育部重点实验室,陕西西安710054 [2]陕西建工安装集团有限公司,陕西西安710054

出　　处：《高分子材料科学与工程》2022年第12期85-92,共8页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(Z2202016);陕西省自然科学基础研究计划(2021SF-497,2022TD-04);中央高校基本科研业务费专项资金(300102290103,300102291403,300102292903);陕西省水利厅项目(2015slkj-02)。

摘　　要：天然小球藻具有独特的理化/生物特性,通过柠檬酸对小球藻进行热化学改性,制备了一种新型复合材料,并将其用作酮洛芬的药物缓释载体。通过红外光谱和扫描电镜分别对合成的柠檬酸交联固定化小球藻复合材料的结构和表面形貌进行表征,提出了材料的合成机理。研究了不同反应温度下合成的复合材料的羧基含量、酯化率、等电荷点等表面属性,确定140℃为最佳的反应温度。此条件下制备的复合材料具有最大的吸水倍率(为35.8 g/g),并对溶胀介质的pH敏感。以酮洛芬为模板药物,研究了柠檬酸交联固定化小球藻复合材料的药物负载性能及在模拟体内环境下的缓释性能,结果表明,pH=1.2和p H=6.8时,经8 h的酮洛芬的累积释放率分别为93.8%和79.7%,该聚合物对抗炎类药物有缓释作用,在智能药物输送方面具有潜在的应用前景。Natural Chlorella has unique physicochemical/biological properties.An eco-friendly composite material was prepared by thermo-chemical modification of Chlorella with citric acid and used as drug release carrier for ketoprofen.The structure and morphology of the synthesized citric acid-Chlorella composites were characterized by FT-IR and SEM,respectively.The surface properties such as carboxyl content,esterification rate,and isoelectric charge point of the composites synthesized at different reaction temperatures were studied,and 140℃is determined as the optimal reaction temperature.The composite prepared under this condition has the maximum water absorption multiplicity of 35.8 g/g and exhibits a sensitivity to p H of swelling medium.The drug loading performance of citric acid cross-linked immobilized Chlorella vulgaris composites and the slow release performance under simulated in vivo environment were investigated using ketoprofen as template drug.The results show that the cumulative release rate of ketoprofen after 8 h is 93.8%and 79.7%at pH=1.2 and pH=6.8,respectively,and the polymer has a slow release effect on anti-inflammatory drugs with potential applications.

关 键 词：固定化技术 水凝胶 溶胀 药物负载 缓释 

分 类 号：TQ460.4[化学工程—制药化工]