A Dipolar Cyclization/Fragmentation Strategy for the Catalytic Asymmetric Synthesis of Chiral Eight-Membered Lactams  

作　　者：Mao-Mao Zhang Peng Chen Wei Xiong Xin-Shang Hui Liang-Qiu Lu Wen-Jing Xiao 

机构地区：[1]CCNU-uOttawa Joint Research Centre,Key Laboratory of Pesticide and Chemical Biology,Ministry of Education,College of Chemistry,Central China Normal University,Wuhan 430079 [2]State Key Laboratory for Oxo Synthesis and Selective Oxidation,Lanzhou Institute of Chemical Physics(LICP),Chinese Academy of Sciences,Lanzhou 730000 [3]State Key Laboratory of Applied Organic Chemistry,Department of Chemistry,Lanzhou University,Lanzhou 730000

出　　处：《CCS Chemistry》2022年第8期2620-2629,共10页中国化学会会刊（英文）

基　　金：from the National Natural Science Foundation of China(nos.21822103,21772052,21772053,21820102003,and 91956201);the Program of Introducing Talents of Discipline to Universities of China(111 Program,B17019);the Natural Science Foundation of Hubei Province(no.2017AHB047)。

摘　　要：Medium-sized nitrogen heterocycles,including eightmembered lactams,are important in synthetic and pharmaceutical chemistry because of their presence in a variety of natural products and drug molecules.Previous attempts at synthesis using a direct headto-tail cyclization strategy suffered from competitive self-cyclization and oligomerization of dipolar species.Herein,we propose an alternative strategy.

关 键 词：asymmetric catalysis dipolar cyclization FRAGMENTATION eight-membered lactams 

分 类 号：O62[理学—有机化学]