Enzyme-like C-H Oxidation of Glucosides Promoted by Visible Light  

作　　者：Mingzhong Wu Qian Jiang Qiong Tian Tianyun Guo Feng Cai Shouchu Tang Jian Liu Xiaolei Wang 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry,Department of Chemistry and School of Pharmacy,Lanzhou University,Lanzhou 730000 [2]State Key Laboratory of Veterinary Etiological Biology,OIE/National Foot and Mouth Disease Reference Laboratory,Lanzhou University,Lanzhou 730000 [3]The National Glycoengineering Research Center,Shandong Provincial Key Laboratory of Carbohydrate Chemistry and Glycobiology,Shandong University,Qingdao 266237

出　　处：《CCS Chemistry》2022年第11期3599-3608,共10页中国化学会会刊（英文）

基　　金：Financial support for this work was provided by the National Science Foundation of China(grant no.22071087);the Fundamental Research Funds for the Central Universities(grant no.lzujbky-2021-ct05);the Open Projects Funds of Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology,Shandong University(grant no.2019CCG05).X.W.also thanks the Thousand Young Talents Program and Longyuan Talents Program for financial support.

摘　　要：To match nature’s prowess at using enzymes to make desired motifs in a regioselective fashion,we explore the use of visible light for the selective oxidation of the hydroxyl group to afford the corresponding ketosaccharide.This highly admirable approach offers several advantages over the enzymatic approach in terms of yields and the scope of substrates.Herein,we report the development of a simple visiblelight-promoted selective oxidation of unprotected glucosides that allows for inexpensive access to valuable keto-saccharide building blocks.The method is employed on a variety of different natural and artificial glucosides,is operationally simple and scalable,and can be used to access keto-saccharides rapidly and inexpensively.

关 键 词：keto-saccharide selective oxidation unprotected glucoside VISIBLE-LIGHT 

分 类 号：O62[理学—有机化学]