Peyer结介导的小肠黏膜免疫及其物种间差异的研究进展  

Peyer’s patch mediated small intestinal mucosal immunity and its differences among species

作　　者：沈阳 孙静[2,3,4,5] 葛良鹏 张进威(指导)[2,3,4,5] 李周权(指导) SHEN Yang;SUN Jing;GE Liangpeng;ZHANG Jinwei;LI Zhouquan(Key Laboratory for Bio-Feed and Molecular Nutrition,College of Animal Science and Technology,Southwest University,Chongqing 400715,China)

机构地区：[1]西南大学动物科学技术学院生物饲料与分子营养实验室,重庆400715 [2]重庆市畜牧科学院,重庆402460 [3]农业农村部养猪科学重点实验室,重庆402460 [4]重庆市养猪科学重点实验室,重庆402460 [5]重庆市医用动物资源开发与转化应用工程技术中心,重庆402460

出　　处：《中国免疫学杂志》2022年第23期2919-2926,共8页Chinese Journal of Immunology

基　　金：国家自然科学基金面上项目(32072687);重庆市自然科学基金面上项目(cstc2021jcyj-msxmX0630);重庆市科研机构绩效引导专项(20524);重庆市畜牧科学院博士科研启动项目(21522)。

摘　　要：肠道不仅是消化吸收营养物质并进行新陈代谢的消化器官,也是抵抗病原体入侵的免疫器官,在机体免疫功能中扮演重要角色。Peyer结位于肠相关淋巴组织的诱导部位,是小肠黏膜免疫的重要组织,是产生IgA的主要来源。本文阐述了Peyer结的组织学特征,重点归纳了Peyer结主要的免疫细胞类型及其参与的黏膜免疫过程,并对人及主要模式动物Peyer结的研究现状进行综述,以期为后续深入研究Peyer结介导的黏膜免疫提供基础资料。Intestinal tract is not only a digestive organ to digest and absorb nutrients for metabolism,but also an immune organ to resist the invasion of foreign pathogen.It plays an important role in immune function.Peyer’s patch,located at the induction site of gut-associated lymphoid tissue,is an important tissue for intestinal mucosal immunity and the main source of IgA production.In this review,we describe the histological characteristics of Peyer’s patch,summarize the main immune cell types and the mucosal immune processes of Peyer’s patch,and review the research status of Peyer’s patch in humans and the main model animals,aiming to provide fundamental information for studying on Peyer’s patch mediated mucosal immunity.

关 键 词：肠道黏膜免疫 Peyer结 IGA 物种间差异 

分 类 号：R392.1[医药卫生—免疫学]