血细胞及其衍生物与冠心病药物涂层球囊介入治疗预后的关系  

Relationship between blood cells and their derivatives and prognosis of drug balloon interventional therapy for coronary heart disease

作　　者：张梅静[1] 陈传军[1] 高炬[1] 曲涛[1] 张萌[1] 翟东东 ZHANG Mei-jing;CHEN Chuan-jun;GAO Ju;QU Tao;ZHANG Meng;ZHAI Dong-dong(Department of Cardiology,Aerospace Center Hospital,Beijing 100049,China)

机构地区：[1]北京航天中心医院心脏医学部,北京100049

出　　处：《中国介入心脏病学杂志》2022年第12期916-922,共7页Chinese Journal of Interventional Cardiology

基　　金：中国航天科工集团公司医疗卫生科研项目(2020-LCYL-004)。

摘　　要：目的评价血细胞及其衍生物与冠心病药物涂层球囊(DCB)介入治疗预后的关系。方法回顾性分析2016年1月至2021年12月于航天中心医院因冠心病应用DCB介入治疗的患者197例,根据介入术后1年内是否发生靶病变血运重建(TLR)进行分组,发生TLR为观察组(38例),未发生TLR为对照组(159例),比较两组患者术前血细胞及其衍生物。比较两组中性粒细胞计数/淋巴细胞计数(NLR)和血小板计数/淋巴细胞计数(PLR)的差异,并绘制NLR和PLR预测TLR的受试者工作特征曲线(ROC)。结果两组患者治疗前一般临床特征比较差异均无统计学意义(均P>0.05),观察组与对照组相比,在DCB介入治疗前的NLR和PLR水平均显著升高,差异均有统计学意义(均P<0.05)。多因素Logistic回归分析显示,NLR(OR 0.175,95%CI0.061~0.496,P=0.001)、PLR(OR0.159,95%CI0.050~0.503,P=0.002)是预测DCB介入治疗后发生TLR的独立危险因素。PLR预测TLR的最佳截断值为140.21,敏感度为81.6%,特异度为61.0%;NLR预测TLR的最佳截断值为3.21,敏感度为84.2%,特异度为61.3%。结论NLR、PLR升高对冠心病DCB介入术后TLR具有一定的预测价值。Objective To evaluate the relationship between blood cells and their derivatives and the prognosis of drug balloon interventional therapy for coronary heart disease.Methods A retrospective analysis of 197 patients treated with drug balloon interventional therapy for coronary heart disease in Aerospace Center Hospital from January 2016 to December 2021 was carried out.Patients were grouped according to whether target lesion revascularization(TLR)occurred within 1 year after intervention.The patients were divided into observation group(38 cases)and control group(159 cases).The preoperative blood cells and their derivatives of the two groups were counted.The dif ferences of neutrophil lymphocyte ratio(NLR)and platelet/lymphocyte ratio(PLR)between the two groups were compared,and the receiver operating characteristic curve(ROC)of PLR and NLR predicting TLR was drawn.Results There was no signifi cant dif ference in general clinical characteristics between the two groups before treatment(all P>0.05).Compared with the control group(159 cases),the levels of PLR and NLR in the observation group(34 cases)were signifi cantly higher before drug balloon intervention(both P<0.05).After multivariate logistic regression analysis,NLR(OR 0.175,95%CI 0.061—0.496,P=0.001),PLR(OR 0.159,95%CI 0.050—0.503,P=0.002)were independent predictors of TLR after DCB treatment.The optimal cutoff value of TLR predicted by PLR was 140.21,the sensitivity was 81.6%and the specifi city was 61.0%.The optimal cutoff value of TLR predicted by NLR was 3.21,the sensitivity was 84.2%and the specifi city was 61.3%.Conclusions The increase of NLR and PLR has a certain predictive value for TLR after drug balloon intervention in coronary heart disease.

关 键 词：药物涂层球囊 血细胞及其衍生物 靶病变血运重建 

分 类 号：R541[医药卫生—心血管疾病]