基于临床病理特征分析子宫内膜癌患者的MTA-1、IL-6和HIF-1α的表达情况及临床变化机制  

The expression of MTA-1,IL-6 and HIF-1αin patients with endometrial cancer were analyzed based on clinicopathological features and the clinical mechanism

作　　者：郑瑜 梁燕茹 李倩 ZHENG Yu;LIANG Yanru;LI Qian(Department of Obstetrics and Gynecology,Shijiazhuang Maternal and Child Healthcare Hospital,Shijiazhuang,Hebei 050050,China;Department of Obstetrics and Gynecology,Baoding Maternal and Child Health Hospital,Baoding,Hebei 071000,China)

机构地区：[1]石家庄市妇幼保健院妇产科,河北石家庄050050 [2]保定市妇幼保健院妇产科,河北石家庄071000

出　　处：《中国优生与遗传杂志》2022年第11期1927-1932,共6页Chinese Journal of Birth Health & Heredity

基　　金：河北省医学科学研究课题(20201429)。

摘　　要：目的分析子宫内膜癌(EC)患者临床病理特征与转移相关基因1(MTA-1)、白细胞介素6(IL-6)及缺氧诱导因子1α(HIF-1α)表达间的关系及临床机制说明。方法选取2019年5月至2021年5月在石家庄市妇幼保健院经手术切除的183例子宫内膜组织,包含75例EC组织、67例不典型增生及41例正常子宫内膜组织,免疫组化与酶联免疫吸附法分别检测不同组织中MTA-1、IL-6、HIF-1α的阳性表达率及表达量,观察其与EC患者临床病理特征的关系;随访截至2022年5月,绘制Kaplan-Meier观察MTA-1、IL-6、HIF-1α的阳性表达EC患者的预后情况;绘制ROC曲线观察MTA-1、IL-6、HIF-1α联合检测对EC患者预后的评估效能并分析其可能的变化机制。结果EC组MTA-1、IL-6、HIF-1α阳性表达率及表达量均显著高于不典型增生组与正常组(P<0.05);EC患者MTA-1、IL-6、HIF-1α阳性表达均与FIGO分期、淋巴结转移、分化程度及浸润深度之间有密切联系,此外IL-6的阳性表达还与肿瘤直径之间有重要关系(P<0.05);Kaplan-Meier显示MTA-1、IL-6、HIF-1α阳性表达患者的生存期均短于阴性患者(χ^(2)=5.260、3.941、5.419,均P<0.05);ROC曲线显示察MTA-1、IL-6、HIF-1α联合检测的曲线下面积显著高于任一单一检测,敏感度为89.80%,特异度为88.50%,对预测EC患者预后具有较高效能。结论MTA-1、IL-6、HIF-1α表达均与EC发展过程具有密切联系,能够作为临床诊治及预后评估的指导依据。Objective To analyze the relationship between clinicopathological features of endometrial carcinoma(EC)and expression of metastasis-associated gene 1(MTA-1),interleukin-6(IL-6)and hypoxia-inducible factor 1α(HIF-1α)and its clinical mechanism.Methods From May 2019 to May 2021,183 cases of intrauterine tissue resected by surgery in Shijiazhuang Maternal and Child Healthcare Hospital were selected,including 75 cases of EC tissue,67 cases of atypical hyperplasia and 41 cases of normal endometrial tissue.The positive expression rates and levels of MTA-1,IL-6 and HIF-1αin different tissues were detected by immunohistochemistry and enzyme-linked immunosorbent assay.The relationship between EC and clinicopathological parameters was analyzed.Follow-up up to May 2022,Kaplan-meier was used to observe the prognosis of EC patients with positive expression of MTA-1,IL-6 and HIF-1α.ROC curve was drawn to observe the efficacy of combined detection of MTA-1,IL-6 and HIF-1αin evaluating the prognosis of EC patients and to analyze its possible mechanism.Results The positive expression rates and levels of MTA-1,IL-6 and HIF-1αin EC group were significantly higher than those in atypical hyperplasia group and normal group(P<0.05).The positive expressions of MTA-1,IL-6 and HIF-1αin EC patients were closely correlated with FIGO stage,lymph node metastasis,degree of differentiation and depth of invasion,and the positive expression of IL-6 was also significantly correlated with tumor diameter(P<0.05).Kaplan-meier showed that patients with positive MTA-1,IL-6 and HIF-1αexpression had shorter survival than those with negative expression(χ^(2)=5.260,3.941,5.419,all P<0.05).The ROC curve showed that the area under the curve of MTA-1,IL-6 and HIF-1αcombined detection was significantly higher than that of any single detection,with a sensitivity of 89.80%and a specificity of 88.50%,which had a high efficacy in predicting the prognosis of EC patients.Conclusion The expression of MTA-1,IL-6 and HIF-1αare closely related to the developme

关 键 词：转移相关基因1 白细胞介素6 缺氧诱导因子1Α 子宫内膜癌 

分 类 号：R737.33[医药卫生—肿瘤]