基于数据挖掘的《中华医典》中胁痛的组方用药规律研究  

Study on medication rules in ancient Chinese Medical Code for the treatment of hypochondriac pain prescriptions based on data mining

作　　者：崔欣怡 姜晓丹 油红捷[2] 唐佐青[2] 马赟[1] 杨铮[1] 车念聪[1] 刘文兰[1] CUI Xinyi;JIANG Xiaodan;YOU Hongjie;TANG Zuoqing;MA Yun;YANG Zheng;CHE Niancong;LIU Wenlan(School of Traditional Chinese Medicine,Capital Medical University,Beijing100069,China;School of Basic Medical Sciences,Capital Medical University,Beijing100069,China)

机构地区：[1]首都医科大学中医药学院,北京100069 [2]首都医科大学基础医学院,北京100069

出　　处：《中国医药导报》2023年第3期4-8,19,共6页China Medical Herald

基　　金：国家自然科学基金资助项目(81573879);北京市自然科学基金面上项目(7182021)。

摘　　要：目的探析《中华医典》所载的治疗胁痛处方的用药规律。方法收集《中华医典》中治疗胁痛的处方,利用Excel(Microsoft Office 2019)录入处方数据及药物信息,对药物功效、四气五味、归经等进行频次统计。用SPSS Modeler 18.0及Cytoscape 3.9.1统计药物共现频次并进行可视化网络展示。用R语言arules包及arules Viz包对筛选处方中的药物进行关联规则分析及可视化,使用SPSS Statistics 19.0对高频药物进行聚类分析。结果共筛选出359首有效处方,使用中药240味,总用药频次3032次,核心药物有当归、甘草、白芍、柴胡、青皮、陈皮等,主要以补虚、理气、活血化瘀药三类药物为主。药物四气以温性为主,药物五味偏辛、苦、甘味,归经主要以脾、肝、肺、胃、心经为主。关联规则分析得到药物关联规则15组,以半夏,生姜与甘草的置信度最高,15组药物关联规则组合功效主要以补气、养血、行气、化瘀、除湿热为主。高频药物可以聚为5类,以疏肝解郁、清热燥湿、行气止痛、活血化瘀为主。结论《中华医典》记载治疗胁痛处方呈现以疏肝行气、活血化瘀、柔肝止痛、化痰燥湿、扶正补虚为主的组方规律,与胁痛的核心病机相符,为临床中医治疗胁痛提供参考。Objective To explore the medication rules of the prescriptions for the treatment of hypochondriac pain contained in the Chinese Medical Code.Methods Prescriptions for the treatment of hypochondriac pain in the Chinese Medical Code were collected,prescription data and drug information were input by Excel(Microsoft Office 2019),and frequency statistics were made on drug efficacy,four nature of drugs and five flavours,and channel tropism.SPSS Modeler 18.0 and Cytoscape 3.9.1 were used to calculate drug co-occurrence frequency and perform visual network display.Association rule analysis and visualization of the drugs in the screened prescriptions were performed using arules and arules Viz packages in R software,and clustering analysis of high-frequency drugs was performed using SPSS Statistics 19.0.Results A total of 359 effective prescriptions were screened,and 240 flavors of traditional Chinese medicine were used,with a total medication frequency of 3032 times.The core drugs were Angelicae Sinensis Radix,Glycyrrhizae Radix et Rhizoma,Paeoniae Radix Alba,Bupleuri Radix,Citri Reticulatae Pericarpium Viride,Citri Reticulatae Pericarpium,and so on.Three types of drugs were mainly used to tonify deficiency,regulate qi,and promote blood circulation for removing blood stasis.The four nature of drugs were mainly warm,the five flavours were mainly pungent,bitter,and sweet,and the channel tropism was mainly spleen,liver,lung,stomach,and heart channels.The association rule analysis yielded 15 groups of drug association rules,with the highest confidence level of Pinelliae Rhizoma,Zingiberis Rhizoma Recens and Glycyrrhizae Radix et Rhizoma.The efficacy of the 15 groups of drug association rules was mainly based on tonifying qi,nourishing blood,promoting qi,resolving blood stasis,and removing dampness and heat.High-frequency drugs could be clustered into five categories,mainly soothing liver-qi stagnation,clearing heat and promoting dampness,activating qi and relieving pain,promoting blood circulation and removing blood stasis.C

关 键 词：胁痛 中华医典 方剂 用药规律 数据挖掘 

分 类 号：R285[医药卫生—中药学]