癌因性疲乏的证候特征及用药规律分析  

Analysis on the syndrome characteristics and medication rule of cancer-related fatigue

作　　者：宋金洁 李中玉 张钟玥 郭中宁[1] 吴煜[1] 臧明轩 SONG Jinjie;LI Zhongyu;ZHANG Zhongyue;GUO Zhongning;WU Yu;ZANG Mingxuan(Department of Oncology,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing100091,China;College of Graduate,China Academy of Chinese Medical Sciences,Beijing100700,China)

机构地区：[1]中国中医科学院西苑医院肿瘤科,北京100091 [2]中国中医科学院研究生院,北京100700

出　　处：《中国医药导报》2023年第3期15-19,共5页China Medical Herald

基　　金：国家重点研发计划-中医药现代化研究项目(2017YFC1700606);中国中医科学院西苑医院苗圃课题(2019XYMP-29)。

摘　　要：目的采用数据挖掘的方法分析癌因性疲乏的中医证候及中药处方的用药规律。方法检索CNKI、CBM、万方、维普和Pub Med数据库自建库至2021年4月关于中医药治疗癌因性疲乏的相关文献,借助中医传承辅助平台V2.5,应用系统集成的统计分析、关联分析、聚类分析和复杂网络分析等方法,分析证候特征、用药规律,获得核心药物配伍及新组方。结果共收集76篇文献。纳入分析的证型共计20个,涉及药物166味,药味为甘温为主,归经主要集中在脾、肝、肺。经关联规则分析,得到关联规则12条,高频中药可聚为3类,核心处方以补中益气汤加减。结论本研究通过数据挖掘对中医药治疗癌因性疲乏处方用药规律进行总结,为临床用药提供借鉴和指导。Objective To analyze the traditional Chinese medicine syndromes of cancer induced-related fatigue and the medication rule of traditional Chinese medicine prescription.Methods In this study,the relevant literature on traditional Chinese medicine treatment of cancer-related fatigue was retrieved from CNKI,CBM,Wanfang,VIP,and Pub Med databases until April 2021,and the syndrome characteristics and medication rule were analyzed by means of the traditional Chinese medicine inheritance auxiliary platform V2.5 and the statistical analysis,association analysis,cluster analysis,and complex network analysis methods of system integration.Core drug compatibility and new formulation were obtained.Results A total of 76 literatures were collected.A total of 20 syndrome types were included in the analysis,involving 166 drugs.The main drug tastes were sweet and warm,and the channel transformation mainly concentrated in the spleen,liver,and lung.After the analysis of association rules,12 association rules were obtained.The high frequency traditional Chinese medicine could be grouped into three categories.The core prescription was modified Buzhong Yiqi Decoction.Conclusion This study summarize the prescription medication rules of traditional Chinese medicine treatment of CRF through data mining,so as to provide reference and guidance for clinical medication.

关 键 词：癌因性疲乏 用药规律 中医证候 数据挖掘 

分 类 号：R273[医药卫生—中西医结合]