三金汤联合西药对肝胆湿热证梗阻性肾病患者肾功能及氧化应激水平的影响  

Effects of Sanjin Decoction combined with western medicine on renal function and oxidative stress level in obstructive nephropathy patients with syndrome of dampness-heat of liver and gallbladder

作　　者：姜坤[1] 刘军 房勇 JIANG Kun;LIU Jun;FANG Yong(Department of Urology and Nephrology,Bengbu Traditional Chinese Medicine Hospital,Anhui Province,Bengbu233002,China)

机构地区：[1]安徽省蚌埠市中医医院泌尿肾病科,安徽蚌埠233002

出　　处：《中国医药导报》2023年第3期75-78,共4页China Medical Herald

基　　金：安徽省自然科学基金青年基金项目(1808085QH279)。

摘　　要：目的 探讨三金汤联合西药对肝胆湿热证梗阻性肾病患者肾功能及氧化应激水平的影响。方法 选取2018年12月至2021年12月安徽省蚌埠市中医医院就诊的165例梗阻性肾病患者,采用随机数字表法将其分为三金汤组、西药组、联合组,每组55例。三组均接受手术和常规药物治疗,三金汤组术后服用三金汤,西药组术后口服依那普利,联合组术后服用三金汤和依那普利,疗程均为3个月。比较三组治疗前后的血尿素氮(BUN)、血清肌酐(SCr)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平及健康调查量表36(SF-36)评分、肾病相关生活质量量表评分。结果 治疗后,三组BUN、SCr、SOD均低于治疗前,MDA及SF-36评分、肾病相关生活质量量表评分均高于治疗前,且联合组BUN、SCr、SOD均低于低于三金汤组、西药组,MDA及SF-36评分、肾病相关生活质量量表评分均高于三金汤组、西药组,差异有统计学意义(P<0.05)。结论 三金汤联合西药用于肝胆湿热证梗阻性肾病患者术后可更好地保护患者的肾功能,抑制氧化应激反应,值得临床推广应用。Objective To investigate the effect of Sanjin Decoction combined with western medicine on renal function and oxidative stress level in obstructive nephropathy patients with syndrome of dampness-heat of liver and gallbladder.Methods A total of 165 patients with obstructive nephropathy treated in the Bengbu Traditional Chinese Medicine Hospital,Anhui Province from December 2018 to December 2021 were selected and divided into Sanjin Decoction group, western medicine group, and combined group by random number table method, with 55 cases in each group. All the three groups received surgery and conventional drug treatment, Sanjin Decoction group received Sanjin Decoction after surgery, western medicine group received Enalapril after surgery, combined group received Sanjin Decoction and Enalapril after surgery, the course of treatment was three months. The levels of blood urea nitrogen(BUN), serum creatinine(SCr), superoxide dismutase(SOD), malondialdehyde(MDA), and scores of short form 36(SF-36), kidney disease-related quality of life scale before and after treatment were compared among the three groups. Results After treatment, BUN, SCr, and SOD of the three groups were lower than those before treatment, MDA, and scores of SF-36, kidney disease-related quality of life scale were higher than those before treatment. In addition, BUN, SCr, and SOD in combined group were lower than those in Sanjin Decoction group and western medicine group, MDA, and scores of SF-36, kidney disease-related quality of life scale were higher than those in Sanjin Decoction group and western medicine group, the differences were statistically significant(P <0.05).Conclusion Sanjin Decoction combined with western medicine can better protect renal function and inhibit oxidative stress in obstructive nephropathy patients with syndrome of dampness-heat of liver and gallbladder after surgery, which is worthy of clinical application.

关 键 词：三金汤 梗阻性肾病 手术 肾功能 氧化应激 

分 类 号：R692.2[医药卫生—泌尿科学]