重组α干扰素-2b雾化吸入联合胸壁振动治疗小儿毛细支气管炎的效果及对免疫功能的影响  

Effect of recombinant interferon α-2b inhalation combined with chest wall vibration in the treatment of children with bronchiolitis and its effect on immune function

作　　者：余晓 周艳 李聃 朱占魁 YU Xiao;ZHOU Yan;LI Dan;ZHU Zhankui(The First Department of Pediatrics,Fuyang Women’s and Children’s Hospital,Anhui Province,Fuyang 236504,China)

机构地区：[1]安徽省阜阳市妇女儿童医院儿一科,安徽阜阳236504

出　　处：《中国医药导报》2023年第2期84-87,共4页China Medical Herald

摘　　要：目的 探讨重组α干扰素-2b雾化吸入联合胸壁振动治疗小儿毛细支气管炎的效果及对免疫功能的影响。方法 选取安徽省阜阳市妇女儿童医院2018年3月至2021年5月收治的120例毛细支气管炎患儿作为研究对象。按照随机数字表法将其分为联合组、观察组和对照组,每组40例。联合组采用重组α干扰素-2b雾化吸入联合胸壁振动治疗,观察组采用重组α干扰素-2b雾化吸入治疗,对照组采用胸壁振动治疗,共治疗7 d。比较各组临床疗效;比较各组治疗前后白细胞介素-6(IL-6)、免疫球蛋白G(Ig G)、Ig A、Ig E和嗜酸性粒细胞(EOS)表达;比较各组随访6个月的复发率。结果 联合组临床疗效优于观察组和对照组(P<0.05)。治疗后,各组IL-6、Ig E、EOS低于治疗前;IgG高于治疗前(P<0.05)。治疗后,联合组IL-6、Ig E、EOS低于观察组和对照组;IgG高于观察组和对照组(P<0.05)。联合组复发率低于观察组和对照组(P<0.05)。结论 重组α干扰素-2b雾化吸入联合胸壁振动治疗对于小儿毛细支气管炎具有良好的效用价值,其能有效减轻患儿的临床症状,调节免疫功能,具有更好的应用价值。Objective To investigate the effect of recombinant interferon α-2b inhalation combined with chest wall vibration in the treatment of children with bronchiolitis and its effect on immune function.Methods A total of 120 children with bronchiolitis admitted to Fuyang Women’s and Children’s Hospital from March 2018 to May 2021 were selected as the research subjects.They were divided into combination group,observation group,and control group,with 40 cases in each group.The children in combination group received recombinant interferon α-2b inhalation combined with chest wall vibration therapy,observation group received recombinant interferon α-2b inhalation therapy,and control group received chest wall vibration therapy.The treatment lasted for seven days.The clinical efficacy of each group was compared;the expressions of interleukin-6(IL-6),immunoglobulin G(Ig G),Ig A,Ig E,and eosinophil(EOS) were compared before and after treatment;the recurrence rate of each group was compared after six months of follow-up.Results The clinical efficacy of combination group was better than that of observation group and control group(P<0.05).After treatment,IL-6,Ig E,and EOS were lower than those before treatment;Ig G was higher than that before treatment(P<0.05).After treatment,IL-6,Ig E,and EOS in combination group were lower than those in observation group and control group;Ig G was higher than that in observation group and control group(P <0.05).The recurrence rate of combination group was lower than that of observation group and control group(P<0.05).Conclusion Recombinant interferon α-2b inhalation combined with chest wall vibration therapy has good utility value for children with bronchiolitis,it can effectively reduce the clinical symptoms of children,and regulate the immune function,and has a better application value.

关 键 词：小儿毛细支气管炎 重组干扰素Α-2B 振动排痰 疗效 免疫调节 

分 类 号：R725.6[医药卫生—儿科]