龟甲健骨胶囊对老年股骨粗隆间骨折内固定术患者骨折端血运及愈合的影响  

Effects of Guijia Jiangu Capsules on Blood Supply and Healing of Fracture End in Elderly Patients with Intertrochanteric Fracture of Femur Undergoing Internal Fixation

作　　者：向杰 屈鑫 赵小敏 李多 XIANG Jie;QU Xin;ZHAO Xiaomin;LI Duo(Dept.of Orthopedics,Nanchong Hospital of Traditional Chinese Medicine,Sichuan Nanchong 637000,China;Dept.of Internal Medicine,Nanchong Hospital of Traditional Chinese Medicine,Sichuan Nanchong 637000,China;Dept.of Outpatient,Nanchong Hospital of Traditional Chinese Medicine,Sichuan Nanchong 637000,China)

机构地区：[1]南充市中医医院骨伤二科,四川南充637000 [2]南充市中医医院内三科,四川南充637000 [3]南充市中医医院门诊部,四川南充637000

出　　处：《中国医院用药评价与分析》2023年第1期62-64,69,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：四川省中医药管理局科学技术研究专项课题(No.2021MS430)。

摘　　要：目的:探讨龟甲健骨胶囊对老年股骨粗隆间骨折(IFOF)内固定术患者骨折端血运及愈合的影响。方法:选取2020-2021年该院收治的老年IFOF患者136例,经随机数字表法分为观察组(n=68)及对照组(n=68)。对照组患者采用股骨近端抗旋髓内钉(PFNA)内固定术,观察组患者在此基础上采用龟甲健骨胶囊治疗。比较两组患者的临床疗效、恢复时间,治疗前后髋关节功能、血清缺氧诱导因子1α(HIF-1α)和血管内皮生长因子(VEGF)水平,以及术后并发症发生情况。结果:观察组患者治疗总有效率为94.12%(64/68),高于对照组的82.35%(56/68),差异有统计学意义(P<0.05)。观察组患者患肢消肿时间、骨折愈合时间明显短于对照组,差异均有统计学意义(P<0.05)。观察组患者治疗2、3个月后的Harris评分均高于对照组,差异均有统计学意义(P<0.05)。观察组患者治疗后血清HIF-1α、VEGF水平高于对照组,差异均有统计学意义(P<0.05)。观察组患者术后并发症发生率为4.41%(3/68),低于对照组的14.71%(10/68),差异有统计学意义(P<0.05)。结论:龟甲健骨胶囊对老年IFOF内固定术患者具有确切的疗效,能缩短患肢消肿时间,促进骨折愈合及髋关节功能恢复,调节血清HIF-1α、VEGF水平,减少术后并发症。OBJECTIVE: To probe into the effects of Guijia Jiangu capsules on blood supply and healing of fracture end in elderly patients with intertrochanteric fracture of femur(IFOF) undergoing internal fixation. METHODS: A total of 136 elderly patients with IFOF admitted into this hospital from 2020 to 2021 were selected and divided into observation group(n=68) and control group(n=68) via random number table method. The control group was given proximal femoral nail anti-rotation(PFNA) for internal fixation, while the observation group was treated with Guijia Jiangu capsules based on the control group. The clinical efficacy and the recovery time, the hip joint function, serum hypoxia-inducible factor-1α(HIF-1α) and vascular endothelial growth factor(VEGF) before and after treatment, and incidences of postoperative complications were compared between two groups. RESULTS: The total effective rate of observation group was 94.12%(64/68), which was higher than that of the control group(82.35%, 56/68), with statistically significant difference(P<0.05). The detumescence time of affected limb and healing time of fracture were significantly shorter in the observation group than those in the control group, with statistically significant differences(P<0.05). The Harris scores of the observation group at 2 months and 3 months after treatment were higher than those of the control group, with statistically significant differences(P<0.05). The serum HIF-1α and VEGF levels of the observation group were higher than those of the control group, with statistically significant differences(P<0.05). The incidence of postoperative complications of the observation group was 4.41%(3/68), which was lower than that of the control group(14.71%, 10/68), with statistically significant difference(P<0.05). CONCLUSIONS: The efficacy of Guijia Jiangu capsules on blood supply and healing of fracture end in elderly patients with IFOF undergoing internal fixation is remarkable, which can shorten the detumescence time of affected limb, promote the healing o

关 键 词：股骨粗隆间骨折 老年患者 内固定术 龟甲健骨胶囊 骨折端血运 骨折愈合 

分 类 号：R932[医药卫生—生药学]