间充质干细胞来源外泌体修复炎症损伤的研究进展  

Progress in research on mesenchymal stem cell-derived exosomes in repair of inflammatory injury

作　　者：刚乔健 何斯(综述) 哈小琴(审校) GANG Qiao-jian;HE Si;HA Xiao-qin(Lanzhou University Second Hospital,Lanzhou 730000,Gansu Province,China)

机构地区：[1]兰州大学第二临床医学院,甘肃兰州730000 [2]中国人民解放军联勤保障部队第九四〇医院检验科,甘肃兰州730050 [3]甘肃省干细胞与基因药物重点实验室,甘肃兰州730050

出　　处：《中国生物制品学杂志》2022年第12期1511-1516,共6页Chinese Journal of Biologicals

基　　金：国家自然科学基金(81273568)。

摘　　要：间充质干细胞(mesenchymal stem cells,MSCs)是一种具有自我更新和多向分化潜力的多能干细胞,能促进组织修复、再生和血管生成,还具有修复炎症损伤的潜力。MSCs来源外泌体(mesenchymal stem cell-derived exosomes,MSC-Exos)具有与MSCs相似的免疫调节和组织修复特性,并具有更高的安全性,可作为一种无细胞疗法替代MSCs治疗炎症损伤相关疾病。本文对MSC-Exos治疗炎症损伤的机制作一综述。Mesenchymal stem cells(MSCs)are multipotent stem cells with self-renewal and multilineage differentiation potential,which can promote tissue repair,regeneration and angiogenesis.In addition,MSCs have the potential to repair inflammatory injury.However,mesenchymal stem cell-derived exosomes(MSC-Exos)have the similar immunomodulatory and tissue-repair properties as MSCs,as well as higher safety,which can be used as a cell-free therapy to replace MSCs to treat inflammatory injury related diseases.This paper reviews the repair mechanism of MSC-Exos on inflammatory injury.

关 键 词：间充质干细胞 外泌体 炎症损伤 免疫 

分 类 号：R392[医药卫生—免疫学]