炎症性肠病患者幽门螺杆菌感染调查及其危险因素分析  

Investigation and Risk Factors of Helicobacter pylori Infection in Patients with Inflammatory Bowel Disease

作　　者：周如宁 张莉[2] 马凯宇[3] 鲍秀琦[4] 王维国 阮戈冲 杨红[1] ZHOU Runing;ZHANG Li;MA Kaiyu;BAO Xiuqi;WANG Weiguo;RUAN Gechong;YANG Hong(Department of Gastroenterology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Department of Gastroenterology,Beijing Shijingshan Hospital,Shijingshan Teaching Hospital of Capital Medical University,Beijing 100043,China;Department of Medical Affairs,Jiamusi Central Hospital,Jiamusi,Heilongjiang 154002,China;Department of Gastroenterology,First Affiliated Hospital of Jiamusi University,Jiamusi,Heilongjiang 154002,China;Department of Gastroenterology,Dezhou Municiple Hospital,Dezhou,Shandong 253012,China)

机构地区：[1]中国医学科学院北京协和医院消化内科,北京100730 [2]首都医科大学教学医院北京市石景山医院消化内科,北京100043 [3]佳木斯市中心医院医务处,黑龙江佳木斯154002 [4]佳木斯大学附属第一医院消化内科,黑龙江佳木斯154002 [5]德州市立医院消化内科,山东德州253012

出　　处：《协和医学杂志》2023年第1期124-130,共7页Medical Journal of Peking Union Medical College Hospital

基　　金：国家临床重点专科能力建设项目(ZK108000);中国医学科学院医学与健康科技创新工程(2022-I2M-C&T-B-011);中央高水平医院临床科研业务费项目(2022-PUMCH-C-018)。

摘　　要：目的探究炎症性肠病(inflammatory bowel disease,IBD)患者幽门螺杆菌(Helicobacter pylori,Hp)感染现况,并初步分析其发生Hp感染的危险因素。方法2020年1月1日—2020年12月31日通过发送电子问卷的方式对北京协和医院长期随访IBD患者及年龄、性别与之相匹配的北京社区居民展开调查。收集两组人群一般资料、Hp感染相关信息、环境因素等资料。比较两组人群Hp阳性率差异并分析IBD患者Hp感染相关危险因素。结果经倾向性评分匹配后,最终纳入本研究IBD患者122例、社区居民1739例。两组人群倾向性评分直方图高度一致。IBD患者Hp阳性率显著低于社区居民(13.1%比42.7%,P<0.001),且两组Hp阳性率均随年龄增高呈逐渐升高趋势,但组内比较差异均无统计学意义(P均>0.05)。单因素分析显示,IBD患者中Hp阳性者长期共餐者Hp感染的比例显著高于Hp阴性者(43.8%比18.9%,P=0.006)。结论IBD患者Hp感染率较社区居民降低,其发生Hp感染可能与长期共餐者Hp阳性有关。Objective To investigate the rate and risk factors of Helicobacter pylori(Hp)infection in patients with inflammatory bowel disease(IBD).Methods A survey was conducted from January 1,2020 to December 31,2020 by sending an electronic questionnaire to long-term follow-up IBD patients of Peking Union Medical College Hospital and age-sex-matched Beijing community residents.General information,information related to Hp infection and environmental factors were collected from the two groups.The differences in Hp positivity rates between the two groups and IBD patients with different clinical profiles were compared.Results After propensity score matching,122 patients with IBD and 1739 community residents were finally included in this study.The histograms of propensity score values were highly consistent between the two groups.The ratio of Hp infection was significantly lower in IBD patients than in the community residents(13.1%vs.42.7%,P<0.001).The ratio of Hp infection in both groups increased with age but showed no statistical significance(all P>0.05).Univariate analysis showed that the IBD patients with Hp positive co-diners had a significantly higher ratio of Hp infection than those with Hp negative co-diners(43.8%vs.18.9%,P=0.006).Conclusions The Hp infection rate was lower in IBD patients than in community residents.The possible risk factor may be co-dining with Hp positives.

关 键 词：炎症性肠病 幽门螺杆菌感染 危险因素 

分 类 号：R593.1[医药卫生—内科学]