土壤中有机肥源抗生素抗性基因环境归趋与风险管理研究进展  

Environmental fate and risk management of manure-borne antibiotic resistance genes in soil:A review

作　　者：王芳[1,2,3] 豆庆圆 付玉豪 梅芝 相雷雷 刘雨 蒋新 SCHAEFFER Andreas[3] 朱永官 TIEDJE James M WANG Fang;DOU Qingyuan;FU Yuhao;MEI Zhi;XIANG Leilei;LIU Yu;JIANG Xin;SCHAEFFER Andreax;ZHU Yongguan;TIEDJE James M(State Key Laboratory of Soil&Sustainable Agriculture,Key Laboratory of Soil Environment and Pollution Remediation,Institute of Soil Science,Chinese Academy of Sciences,Nanjing 210008,China;University of Chinese Academy of Sciences,Beijing 100049,China;Institute for Environmental Research,RWTH Aachen University,Aachen 52074,Germany;Institute of Urban Environment,Chinese Academy of Sciences,Xiamen 361021,China;Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China;Department of Plant,Soil and Microbial Sciences,Michigan State University,East Lansing 48824,USA)

机构地区：[1]中国科学院南京土壤研究所,土壤与农业可持续发展国家重点实验室,中国科学院土壤环境与污染修复重点实验室,南京210008 [2]中国科学院大学,北京100049 [3]亚琛工业大学环境研究所,德国亚琛52074 [4]中国科学院城市环境研究所,福建厦门361021 [5]中国科学院生态环境研究中心,北京100085 [6]密歇根州立大学植物、土壤和微生物学系,美国东兰辛48824

出　　处：《农业环境科学学报》2022年第12期2563-2576,共14页Journal of Agro-Environment Science

基　　金：国家自然科学基金项目(41977137);国际原子能机构研究项目(D15022);德国洪堡资深学者项目;江苏省卓越博士后计划项目(2022ZB460)。

摘　　要：抗生素抗性基因——一类新型污染物,已对人类健康和环境安全构成威胁,如何有效应对日益严峻的耐药性危机已成为一项全球性挑战。有机肥源抗生素抗性基因是土壤抗生素抗性基因的主要来源,而土壤参与并主导不同环境单元中抗生素抗性基因演化的多元交互作用,因此,有必要厘清有机肥源抗生素抗性基因在土壤和其他环境介质中的命运、归趋与风险。本文综述了近年来有机肥源抗生素抗性基因在土壤中的分布特征、环境归趋、人体暴露风险以及风险管理方面的研究进展,并提出建议与展望,以期为有效减轻抗生素抗性基因在环境中的危害,遏制抗生素抗性基因的增殖与传播提供理论依据与决策参考。Antibiotic resistance genes(ARGs),as emerging contaminants,are posing a serious threat to human health and environmental security.How to effectively combat the increasingly severe resistance crisis has become a global challenge.ARGs derived from manure are the main source of ARGs in soil,and involved in the multiple interactions of antibiotic resistance evolution in different environmental components.Therefore,it is of great significance to clarify the fate,dynamics and risk of manure-borne ARGs between soil and other related environmental media.This prospectus reviewed the recent progresses in the distribution characteristics,environmental fate,human exposure risk and effective alleviation strategies of manure-borne ARGs around soil ecosystems,and advanced the recommendations for future research.This review can provide theoretical basis and decision-making reference for effectively reducing the risks of ARGs in the environment.

关 键 词：土壤 有机肥 抗生素抗性基因 环境归趋 阻控技术 风险评估 

分 类 号：X53[环境科学与工程—环境工程]