Base-Promoted Catalyst-Free Regioselective Hydroacylation of Styrenes with Hydrazones via Carbanion Addition  

作　　者：Pan Pan Yatao Lang Dawei Cao Huiying Zeng Chao-Jun Li 

机构地区：[1]The State Key Laboratory of Applied Organic Chemistry,College of Chemistry and Chemical Engineering,Lanzhou University,Lanzhou,730000 Gansu [2]FRQNT Center for Green Chemistry and Catalysis,McGill University,Montreal,Quebec H3A 0B8

出　　处：《CCS Chemistry》2022年第10期3254-3263,共10页中国化学会会刊（英文）

基　　金：from the National Natural Science Foundation of China(grant no.21971093);the International Joint Research Centre for Green Catalysis and Synthesis(grant no.2016B01017),and the 111 project.

摘　　要：Wereport a base-promoted catalyst-free protocol for the highly regioselective hydroacylation of styrenes with hydrazones derived from naturally abundant aldehydes.This protocolgeneratedlinearketoneswith goodfunctional grouptolerance anda broadsubstrate scope under mild conditions.Mechanistic studies showed that the addition of hydrazone anion to a styrene double bond was the key step,different from previoushydroacylationpathways(viaorganometallic complexes or radical intermediates).

关 键 词：CATALYST-FREE regioselective hydroacylation hydrazone carbanion addition base-promoted 

分 类 号：O62[理学—有机化学]