Chiral Sulfide/Phosphoric Acid Cocatalyzed Enantioselective Intermolecular Oxysulfenylation of Alkenes with Phenol and Alcohol O-Nucleophiles  

作　　者：Xiao-Dong Liu Yicong Luo Xiaohong Huo Hui-Yun Luo Ren-Fei Cao Zhi-Min Chen 

机构地区：[1]Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs,School of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai 200240

出　　处：《CCS Chemistry》2022年第10期3342-3354,共13页中国化学会会刊（英文）

基　　金：the National Natural Science Foundation of China(NSFC)(nos.21871178,22071149,21901158,21702135)and the STCSM(no.19JC1430100)for their financial support.

摘　　要：Enantioselective intermolecular three-component oxysulfenylations of alkenes with phenols and alcohols as O-nucleophiles were achieved using chiral BINAM-derived sulfide/phosphoric acid as the cocatalyst.Notably,chiral BINAM-derived sulfide/phosphoric acid co-catalysis was first explored to successfully catalyze highly enantioselective transformation.A variety of sulfur-containing benzylic aryl ethers and benzylic alkyl ethers,which contained two contiguous chiral stereocenters,were obtained readily in moderate to excellent yields with high to excellent enantioselectivities.

关 键 词：dual catalysis enantioselective sulfenylation three-component reaction O-nucleophile contiguous chiral stereocenter 

分 类 号：O62[理学—有机化学]