血清IGF-1、AMH、LH和FINS在多囊卵巢综合征中的表达及诊断价值  

Expression and the diagnostic value of the serum IGF-1,AMH,LH and FINS in polycystic ovary syndrome

作　　者：秦育滨 刘占平 李妙娜 卢军[2] QIN Yu-bin;LIU Zhan-ping;LI Miao-na(Clinical Laboratory Department,Puning Hospital of Traditional Chinese Medicine affiliated to Guangzhou University of Traditional Chinese Medicine/Puning Hospital of Traditional Chinese Medicine,Puning 515300,China)

机构地区：[1]广州中医药大学附属普宁中医医院/普宁市中医医院检验科,515300 [2]广州中医药大学附属普宁中医医院/普宁市中医医院妇科,515300

出　　处：《中国现代药物应用》2023年第2期42-45,共4页Chinese Journal of Modern Drug Application

基　　金：广东省中医药局面上项目(项目编号:20191408);广东省揭阳市科技计划项目(项目编号:YLWS013)。

摘　　要：目的探讨血清胰岛素样生长因子1(IGF-1)、抗缪勒管激素(AMH)、促黄体生成素(LH)和空腹胰岛素(FINS)在多囊卵巢综合征(PCOS)患者中的表达及诊断价值。方法选取150例PCOS患者作为观察组,另选取50例月经规律、排卵正常的女性作为对照组。比较两组血清IGF-1、AMH、LH和FINS水平,分析血清IGF-1、AMH、LH和FINS对PCOS的诊断效能。结果观察组血清IGF-1(154.22±21.98)ng/ml、AMH(11.08±2.23)ng/ml、LH(9.59±1.41)mIU/ml和FINS(13.44±2.97)μIU/ml均高于对照组的(116.96±9.84)ng/ml、(6.26±2.32)ng/ml、(6.87±2.21)mIU/ml、(10.27±1.96)μIU/ml,差异有统计学意义(P<0.05)。IGF-1、AMH、LH及FINS诊断PCOS的受试者工作特征曲线(ROC)的曲线下面积(AUC)分别为0.914、0.928、0.855、0.810,IGF-1、AMH、LH及FINS诊断PCOS的敏感度分别为75.3%、84.0%、84.7%、70.7%,特异度分别为98.0%、84.0%、76.0%、78.0%,最佳截断值分别为135.22 ng/ml、8.50 ng/ml、8.14 mIU/ml、11.40μIU/ml,约登指数分别为0.733、0.680、0.607、0.487。结论血清IGF-1、AMH、LH和FINS在PCOS患者中呈高表达,可作为PCOS临床诊断和治疗的重要辅助指标,但IGF-1和AMH更有诊断价值。Objective To discuss the expression and the diagnostic value of the serum insulin-like growth factor 1(IGF-1),anti-Müllerian hormone(AMH),luteinizing hormone(LH)and fasting insulin(FINS)in polycystic ovary syndrome.Methods 150 patients with PCOS were selected as the observation group,and another 50 women with regular menstruation and normal ovulation were selected as the control group.The serum IGF-1,AMH,LH and FINS levels were compared between the two groups,and the diagnostic efficacy of serum IGF-1,AMH,LH and FINS on PCOS was analyzed.Results The serum IGF-1(154.22±21.98)ng/ml,AMH(11.08±2.23)ng/ml,LH(9.59±1.41)mIU/ml and FINS(13.44±2.97)μIU/ml in the observation group were higher than(116.96±9.84)ng/ml,(6.26±2.32)ng/ml,(6.87±2.21)mIU/ml and(10.27±1.96)μIU/ml in the control group,and the differences were statistically significant(P<0.05).The area under the receiver operating characteristic(ROC)curve(AUC)of IGF-1,AMH,LH and FINS for the diagnosis of PCOS were 0.914,0.928,0.855 and 0.810,respectively.The sensitivity of IGF-1,AMH,LH and FINS for the diagnosis of PCOS were 75.3%,84.0%,84.7%and 70.7%,respectively,the specificity were 98.0%,84.0%,76.0%and 78.0%,respectively,the best cut-off values were 135.22 ng/ml,8.50 ng/ml,8.14 mIU/ml,and 11.40μIU/ml,respectively,and the Youden index were 0.733,0.680,0.607,and 0.487,respectively.Conclusion The serum IGF-1,AMH,LH and FINS are highly expressed in PCOS patients and can be used as important auxiliary indicators for the clinical diagnosis and the treatment of PCOS,but the diagnostic value of IGF-1 and AMH is more meaningful.

关 键 词：多囊卵巢综合征 胰岛素样生长因子1 抗缪勒管激素 促黄体生成素 空腹胰岛素 

分 类 号：R711.75[医药卫生—妇产科学]