脂溶性β-受体阻滞剂对高血压脑卒中患者静息心率的影响研究  

Study on the effect of lipid-solubleβ-blockers on resting heart rate of hypertensive stroke patients

作　　者：刘士宝 LIU Shi-bao(Department of Cardiology,Lingcheng District Hospital of Traditional Chinese Medicine,Dezhou 250100,China)

机构地区：[1]德州市陵城区中医院心内科,250100

出　　处：《中国实用医药》2023年第2期11-14,共4页China Practical Medicine

摘　　要：目的探讨脂溶性β-受体阻滞剂对高血压脑卒中患者静息心率的影响。方法200例高血压脑卒中患者,采用随机数字表法分为对照组与实验组,每组100例;另根据Barthel指数评分出入院差值分为A组(Barthel指数评分出入院差值≥5分,100例)和B组(Barthel指数评分出入院差值<5分,100例)。对照组患者进行常规治疗,实验组患者在对照组基础上给予美托洛尔片治疗。比较实验组和对照组患者不同时间点静息心率、巴塞尔(Barthel)指数评分及治疗前后焦虑自评量表(SAS)和抑郁自评量表(SDS)评分;比较A组与B组患者服用β-受体阻滞剂情况及不同时间点静息心率。结果实验组患者入院时静息心率(73.22±10.62)次/min、随访6个月后静息心率(68.99±9.65)次/min、静息心率平均值(72.25±10.45)次/min与对照组的(72.30±9.94)、(68.67±9.45)、(70.26±10.06)次/min比较,差异均无统计学意义(P>0.05)。实验组患者静息心率出入院差值(6.89±1.69)次/min大于对照组的(1.88±0.99)次/min,差异具有统计学意义(P<0.05)。实验组患者入院时Barthel指数评分(76.59±15.75)分、随访6个月后Barthel指数评分(86.65±14.37)分与对照组的(77.15±14.34)、(85.14±13.78)分比较,差异无统计学意义(P>0.05)。实验组患者Barthel指数评分出入院差值(9.89±2.45)分大于对照组的(5.02±1.85)分,差异均具有统计学意义(P<0.05)。A组患者服用β-受体阻滞剂占比69%、静息心率出入院差值(3.60±1.15)次/min均高于B组的31%、(0.60±0.11)次/min,入院时静息心率(66.80±6.84)次/min、随访6个月后静息心率(64.32±6.70)次/min、静息心率平均值(65.90±6.04)次/min均低于B组的(73.15±6.02)、(71.12±5.14)、(72.36±6.30)次/min,差异均具有统计学意义(P<0.05)。治疗后,实验组患者SAS评分(40.12±3.35)分、SDS评分(43.25±4.62)分均低于对照组的(47.08±3.23)、(50.36±4.85)分,差异均具有统计学意义(P<0.05)。结论脂溶性β-受体阻滞剂在�Objective To discuss the effect of lipid-solubleβ-blockers on resting heart rate and prognosis in hypertensive stroke patients.Methods A total of 200 hypertensive stroke patients were divided into a control group and an experimental group according to random numerical table,with 100 cases in each group.They were also divided into group A(difference between Barthel index scores at admission and discharge≥5 points,100 cases)and group B(difference between Barthel index scores at admission and discharge<5 points,100 cases)according to the difference between Barthel index scores at admission and discharge.The control group was treated conventionally,and the experimental group was treated with metoprolol tablets on the basis of the control group.The resting heart rate and Barthel index score at different time points,self-rating anxiety scale(SAS)score and self-rating depression scale(SDS)score before and after treatment were compared between the experimental group and control group;the administration ofβ-receptor blockers and resting heart rate at different time points were compared between group A and group B.Results The resting heart rate of patients in the experimental group was(73.22±10.62)beats/min at admission and(68.99±9.65)beats/min at 6-month follow-up,with a mean value of(72.25±10.45)beats/min,which were not statistically significant compared with(72.30±9.94),(68.67±9.45),and(70.26±10.06)beats/min in the control group(P>0.05).The difference between the resting heart rate at admission and discharge in the experimental group was(6.89±1.69)beats/min,which was greater than(1.88±0.99)beats/min in the control group,and the difference was statistically significant(P<0.05).The Barthel index scores of the patients in the experimental group was(76.59±15.75)points at admission and(86.65±14.37)points after 6 months of follow-up,which were not significantly different from(77.15±14.34)and(85.14±13.78)points in the control group(P>0.05).The difference between Barthel index scores at admission and discharge i

关 键 词：脂溶性β-受体阻滞剂 高血压 脑卒中 静息心率 美托洛尔 

分 类 号：R544.1[医药卫生—心血管疾病] R743.3[医药卫生—内科学]