针刺作用下嘌呤受体P_(2)X_(7)对神经病理性疼痛的作用  

Effects of purinoceptor P 2X 7 on neuropathic pain under the action of acupuncture

作　　者：高芳芳 李婷婷 崔艺敏 唐娅妮 何轶帆 刘奇 屈红艳 GAO Fangfang;LI Tingting;CUI Yimin;TANG Yani;HE Yifan;LIU Qi;QU Hongyan(School of Acupuncture and Massage,Shaanxi University of Chinese Medicine,Xianyang 712046,China)

机构地区：[1]陕西中医药大学针灸推拿学院,陕西咸阳712046

出　　处：《陕西中医》2023年第2期271-272,F0003,共3页Shaanxi Journal of Traditional Chinese Medicine

基　　金：陕西省科技计划项目(2021JM-469,2022JQ-942)。

摘　　要：嘌呤受体P_(2)X_(7)是P_(2)X家族中具有双功能调节且结构上有别于其他成员的受体,其在神经系统中的表达广泛地参与了疼痛的发生和维持的过程,在神经病理性疼痛的治疗中受到了极大关注。有研究发现,P_(2)X_(7)受体在针刺作用下通过调控其他因子或者通路而在镇痛过程中起关键作用,极可能成为镇痛中重要的干预靶点。但是目前关于针刺镇痛是如何影响P_(2)X_(7)受体等神经递质来抑制神经源性痛觉传递还存在争议,有待进一步深入研究。因此,寻找更加有效的机制来指导临床工作显得尤为重要。现基于针刺治疗对P_(2)X_(7)受体在神经病理性疼痛中的作用进行简要综述,旨在为神经病理性疼痛的治疗提供新的理论依据。The purinergic P_(2)X_(7)receptor is a receptor with bifunctional regulation in the P_(2)X family and is structurally different from other members.Its expression in the nervous system is widely involved in the occurrence and maintenance of pain,and it is widely used in the treatment of neuropathic pain.received a lot of attention.Some studies have found that P_(2)X_(7)receptor plays a key role in analgesia by regulating other factors or pathways under the action of acupuncture,and it is likely to become an important intervention target in analgesia.However,there is still controversy about how acupuncture analgesia affects neurotransmitters such as P 2X 7 receptors to inhibit neurogenic pain transmission,and further research is needed.Therefore,it is particularly important to find a more effective mechanism to guide clinical work.This article briefly reviews the role of P 2X 7 receptors in neuropathic pain based on acupuncture therapy,aiming to provide a new theoretical basis for the treatment of neuropathic pain.

关 键 词：疼痛 P_(2)X_(7)受体 针刺镇痛 嘌呤受体 嘌呤信号通路 

分 类 号：R441.1[医药卫生—诊断学]